Migration of cells toward chemical cues, or chemotaxis, is important for many biologic
processes such as immune defense, wound healing and cancer metastasis. Although …

For metastasis to occur cells must communicate with to their local environment to initiate
growth and invasion. Exosomes have emerged as an important mediator of cell-to-cell …

Small extracellular vesicles called exosomes affect multiple autocrine and paracrine cellular
phenotypes. Understanding the function of exosomes requires a variety of tools, including …

Unconventional secretion of exosome vesicles from multivesicular endosomes (MVEs)
occurs across a broad set of systems and is reported to be upregulated in cancer, where it …

Intercellular communication between cellular compartments within the tumor and at distant
sites is critical for the development and progression of cancer. Exosomes have emerged as …

The tumor microenvironment is replete with factors secreted and internalized by surrounding
cells. Exosomes are nano-sized, protein-embedded, membrane-bound vesicles that are …

Exosomes secreted by normal and cancer cells carry and deliver a variety of molecules. To
date, mechanisms referring to tumor exosome trafficking, including release and cell-cell …

Metastases remain a major cause of cancer morbidity and mortality. This is a multistep
process that involves aberrant cell communication, leading to tumor cell dissemination from …

Exosomes are nano-vesicles secreted by a wide range of mammalian cell types. These
vesicles are abundant in serum and other extracellular fluids and contain a large repertoire …

Tumor-derived exosomes play a multifaceted role in preparing the pre-metastatic niche,
promoting cancer dissemination, and regulating cancer cell dormancy. A brief review of …