Absolute quantitative MALDI imaging mass spectrometry: a case of rifampicin in liver tissues
CW Chumbley, ML Reyzer, JL Allen… - Analytical …, 2016 - ACS Publications
Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS)
elucidates molecular distributions in thin tissue sections. Absolute pixel-to-pixel quantitation …
elucidates molecular distributions in thin tissue sections. Absolute pixel-to-pixel quantitation …
Absolute quantification of rifampicin by MALDI imaging mass spectrometry using multiple TOF/TOF events in a single laser shot
BM Prentice, CW Chumbley… - Journal of the American …, 2016 - ACS Publications
Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) allows
for the visualization of molecular distributions within tissue sections. While providing …
for the visualization of molecular distributions within tissue sections. While providing …
A mimetic tissue model for the quantification of drug distributions by MALDI imaging mass spectrometry
MR Groseclose, S Castellino - Analytical chemistry, 2013 - ACS Publications
The full potential of imaging mass spectrometry (IMS) as a tool in drug development will not
be realized until reliable quantitative information can be integrated with the molecular …
be realized until reliable quantitative information can be integrated with the molecular …
MALDI imaging mass spectrometry for direct tissue analysis: technological advancements and recent applications
B Balluff, C Schöne, H Höfler, A Walch - Histochemistry and cell biology, 2011 - Springer
Matrix assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a
method that allows the investigation of the molecular content of tissues within its …
method that allows the investigation of the molecular content of tissues within its …
[HTML][HTML] Advanced MALDI mass spectrometry imaging in pharmaceutical research and drug development
S Schulz, M Becker, MR Groseclose, S Schadt… - Current opinion in …, 2019 - Elsevier
Highlights•Ideal mass spectrometer for MALDI MSI would satisfy the '4S-criteria for
performance'(speed, specificity, spatial resolution and sensitivity).•Quantification MALDI MSI …
performance'(speed, specificity, spatial resolution and sensitivity).•Quantification MALDI MSI …
Applications of MALDI mass spectrometry imaging for pharmacokinetic studies during drug development
M Nishidate, M Hayashi, H Aikawa, K Tanaka… - Drug metabolism and …, 2019 - Elsevier
The concentration and distribution of a drug or its metabolites in tissues are key factors for
understanding drug efficacy or toxicity. Conventional pharmacokinetic studies show that the …
understanding drug efficacy or toxicity. Conventional pharmacokinetic studies show that the …
Direct molecular analysis of whole-body animal tissue sections by imaging MALDI mass spectrometry
S Khatib-Shahidi, M Andersson, JL Herman… - Analytical …, 2006 - ACS Publications
Imaging mass spectrometry (IMS) that utilizes matrix-assisted laser desorption/ionization
(MALDI) technology can provide a molecular ex vivo view of resected organs or whole-body …
(MALDI) technology can provide a molecular ex vivo view of resected organs or whole-body …
Identifying tissue-specific signal variation in MALDI mass spectrometric imaging by use of an internal standard
Generating analyte-specific distribution maps of compounds in a tissue sample by matrix-
assisted laser desorption/ionization (MALDI) mass spectrometric imaging (MSI) has become …
assisted laser desorption/ionization (MALDI) mass spectrometric imaging (MSI) has become …
[HTML][HTML] Sample preparation of formalin-fixed paraffin-embedded tissue sections for MALDI-mass spectrometry imaging
J Hermann, H Noels, W Theelen, M Lellig… - Analytical and …, 2020 - Springer
Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MALDI
MSI) has become a powerful tool with a high potential relevance for the analysis of …
MSI) has become a powerful tool with a high potential relevance for the analysis of …
Alternative two‐step matrix application method for imaging mass spectrometry to avoid tissue shrinkage and improve ionization efficiency
S Shimma, Y Takashima, J Hashimoto… - Journal of Mass …, 2013 - Wiley Online Library
Mass spectrometry (MS) was used to measure the concentrations of drug and biological
compounds in plasma and tissues. Matrix‐assisted laser desorption/ionization (MALDI) …
compounds in plasma and tissues. Matrix‐assisted laser desorption/ionization (MALDI) …