Neurons are particularly vulnerable to mitochondrial dysfunction due to high energy demand
and an inability to proliferate. Therefore, dysfunctional mitochondria cause various …

The human brain is a highly complex organ with remarkable energy demands. Although it
represents only 2% of the total body weight, it accounts for 20% of all oxygen consumption …

Neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's, and
amyotrophic lateral sclerosis, are characterized by a progressive loss of selective neuron …

The brain evolved cellular mechanisms for adapting synaptic function to energy supply. This
is particularly evident when homeostasis is challenged by stress. Signaling loops between …

Alzheimer's disease (AD) is the inoperable, incapacitating, neuropsychiatric, and
degenerative manifestation that drastically affects human life quality. The current …

It has become increasingly clear that glucocorticoid (GC) signaling not only comprises
classic nuclear receptor binding—that is, glucocorticoid receptors (GRs) to their response …

Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and
characterized by the progressive degeneration of the function and structure of the central …

The structure and function of neurons is dynamic during development and in adaptive
responses of the adult nervous system to environmental demands. The mechanisms that …

Neurodegenerative diseases are incurable and inexorably progressive conditions that affect
the central nervous system and result in a selective pattern of neuronal death. Parkinson's …

Neuronal survival critically depends on the integrity and functionality of mitochondria. A
hierarchical system of cellular surveillance mechanisms protects mitochondria against …