Innate immune cells play important roles in tissue injury and repair following acute
myocardial infarction (MI). Although reprogramming of macrophage metabolism has been …

Despite major progress in interventional and medical treatments, myocardial infarction (MI)
and subsequent development of heart failure (HF) are still associated with high mortality …

As reperfusion therapies have become more widely used in acute myocardial infarction
patients, ischemia-induced myocardial damage has been markedly reduced, but reperfusion …

Using a mitochondria-targeted vitamin E (Mito-Vit-E) in a rat pneumonia-related sepsis
model, we examined the role of mitochondrial reactive oxygen species in sepsis-mediated …

Macrophages are pivotal in the initiation and development of atherosclerotic cardiovascular
diseases. Recent studies have reinforced the importance of mitochondria in metabolic and …

Wound healing is a coordinated process that initially relies on pro-inflammatory
macrophages, followed by a pro-resolution function of these cells. Changes in cellular …

Mitochondria are key regulators of cell fate through controlling ATP generation and
releasing pro-apoptotic factors. Cardiac ischemia/reperfusion (I/R) injury to the coronary …

During the inflammatory response, macrophage phenotypes can be broadly classified as
pro-inflammatory/classically activated “M1”, or pro-resolving/alternatively “M2” …

Thrombolytic therapy and revascularization strategies create a complete recanalization of
the occluded epicardial coronary artery in patients with myocardial infarction (MI). However …

Mitochondria are capable of detecting cellular insults and orchestrating inflammatory
responses. Mitochondrial reactive oxygen species (mtROS) are intermediates that trigger …