It is widely recognized that bi-directional communication exists between the human oocyte
and cumulus cells (CCs) which is essential for the production of competent oocytes. CCs …

Cumulus expansion and oocyte maturation are central processes in ovulation. Knowledge
gained from rodent and other mammalian models has revealed some of the molecular …

Cumulus cells (CCs) originating from undifferentiated granulosa cells (GCs) differentiate in
mural granulosa cells (MGCs) and CCs during antrum formation in the follicle by the …

The bi-directional communication between the oocyte and the surrounding cumulus cells
(CCs) is crucial for the acquisition of oocyte competence. We investigated the transcriptomic …

BACKGROUND Oocyte maturation is under strict regulatory control, not only from intrinsic
cellular processes, but also extrinsic influences. While the oocyte is directly connected to the …

BACKGROUND Oocyte maturation and competence to development depends on its close
relationship with cumulus cells (CCs). However, the maturation conditions of human …

BACKGROUND: The understanding of the mechanisms regulating human oocyte maturation
is still rudimentary. We have identified transcripts differentially expressed between immature …

Ovulation is a complex process initiated by the preovulatory LH surge, characterized by
cumulus oocyte complex (COC) expansion and completed by the release of a mature …

Lack of an objective, accurate, and noninvasive embryo assessment strategy remains one of
the major challenges encountered in in vitro fertilization. Cumulus and mural granulosa cells …

Single-embryo transfer is becoming increasingly common in in vitro fertilization (IVF)
treatment as a means of reducing multiple pregnancy rates leading to a higher incidence of …