Background: Experimental treatments pass through various stages of development. If a
treatment passes through early-phase experiments, the investigators may want to assess it …

Multi‐arm trials are an efficient way of simultaneously testing several experimental
treatments against a shared control group. As well as reducing the sample size required …

Background The multi-arm multi-stage (MAMS) design described by Royston et al.[Stat Med.
2003; 22 (14): 2239–56 and Trials. 2011; 12: 81] can accelerate treatment evaluation by …

Background The multi-arm multi-stage framework uses intermediate outcomes to assess
lack-of-benefit of research arms at interim stages in randomised trials with time-to-event …

Multi-arm clinical trials assessing multiple experimental treatments against a shared control
group can offer efficiency advantages over independent trials through assessing an …

The impact of selection bias on the results of clinical trials has been analyzed extensively for
trials of two treatments, yet its impact in multi-arm trials is still unknown. In this paper, we …

Background Multi-arm trials enable the evaluation of multiple treatments within a single trial.
They provide a way of substantially increasing the efficiency of the clinical development …

Background For many disease areas, there are often treatments in different stages of the
development process. We consider the design of a two-arm parallel group trial where it is …

The article by Parker and Weir1 is another in the long debate of whether it is necessary to
make adjustments for multiple comparisons and, if so, when and how such adjustments …

Platform trials offer a framework to study multiple interventions in one trial with the
opportunity of opening and closing arms. The use of common controls can increase …