Background Testicular architecture and sperm production are supported by a complex
network of communication between various cell types. These signals ensure fertility by …

Sertoli cells are the orchestrators of spermatogenesis; they support fetal germ cell
commitment to the male pathway and are essential for germ cell development, from …

Male fertility is maintained through intricate cellular and molecular interactions that ensure
spermatogonial stem cells (SSCs) proceed in a step-wise differentiation process through …

Spermatogenesis is a complex process by which spermatogonial stem cells (SSCs) self-
renew and differentiate into spermatozoa under the elaborate coordination of testicular …

This review addresses current understanding of the germline stem cell niche unit in
mammalian testes. Spermatogenesis is a classic model of tissue-specific stem cell function …

Contents Spermatogonial stem cells (SSCs) reside within specialized microenvironments
called 'niches', which are essential for their maintenance and self‐renewal. In the …

Human testis development in prenatal life involves complex changes in germline and
somatic cell identity. To better understand, we profiled and analyzed∼ 32,500 single-cell …

In mammalian testes, robust stem cell functions ensure the continual production of sperm. In
testicular seminiferous tubules, spermatogenic stem cells (SSC s) are highly motile and are …

The functions of Sertoli cells in spermatogenesis have attracted much more attention
recently. Normal spermatogenesis depends on Sertoli cells, mainly due to their influence on …

The testis is an endocrine-responsive tissue that requires a number of important cell-cell
interactions for the maintenance and control of cellular growth and differentiation. The Sertoli …