Autoimmune neuroinflammatory diseases are a group of disorders resulting from abnormal
immune responses in the nervous system, causing inflammation and tissue damage. The …

It is becoming increasingly clear that neuroinflammation has a causal role in the
pathogenesis of central nervous system (CNS)-related diseases, and therefore therapeutic …

Multiple sclerosis (MS) is the principal cause of autoimmune neuroinflammation in humans,
and its animal model, experimental autoimmune encephalomyelitis (EAE), is widely used to …

A precise and dynamic immune response is pivotal for maintaining defense against
pathogens, cellular homeostasis, and tissue repair following injury. Dysregulated immune …

There is an increasing recognition that inflammation plays a critical role in
neurodegenerative diseases of the CNS, including Alzheimer's disease, amyotrophic lateral …

Introduction: It has been recognized for about 20 years that interleukin (IL)-1 signaling is
implicated in Multiple Sclerosis (MS), a disabling, chronic, inflammatory and …

Neuroinflammatory and neurodegenerative disorders including Alzheimer's disease (AD),
Parkinson's disease (PD), traumatic brain injury (TBI) and Amyotrophic lateral sclerosis …

In physiological conditions, different types of macrophages can be found within the central
nervous system (CNS), ie, microglia, meningeal macrophages, and perivascular (blood …

The identification of T helper 17 (Th17) cells challenges the Th1/Th2 paradigm of the
immune response and invites intensive exploration of their mechanisms and functions in the …

Multiple sclerosis (MS) is the most common chronic demyelinating disease of the central
nervous system (CNS) and the major cause of neurological disability in young adults in …