COL14A1 promotes self-renewal of human liver cancer stem cells through activation of ERK signaling

R Kong, H Liu, Y Shi, Q Man, S Liu - Journal of Bio-X Research, 2021 - spj.science.org
Objective: Liver cancer stem cells (CSCs) are the culprits of hepatocellular carcinoma
metastasis and recurrence. Only by eliminating tumor stem cells can malignant tumors be …

[HTML][HTML] MicroRNA-302a/d inhibits the self-renewal capability and cell cycle entry of liver cancer stem cells by targeting the E2F7/AKT axis

YS Ma, ZW Lv, F Yu, ZY Chang, XL Cong… - Journal of Experimental …, 2018 - Springer
Background There is increasing evidence that liver cancer stem cells (LCSCs) contribute to
hepatocellular carcinoma (HCC) initiation and progression. MicroRNA (miRNA) plays a …

MicroRNA‐28‐5p regulates liver cancer stem cell expansion via IGF‐1 pathway

Q Xia, T Han, P Yang, R Wang, H Li… - Stem Cells …, 2019 - Wiley Online Library
Background. MicroRNAs (miRNAs) play a critical role in the regulation of cancer stem cells
(CSCs). However, the role of miRNAs in liver CSCs has not been fully elucidated. Methods …

MicroRNA-6838-5p suppresses the self-renewal and metastasis of human liver cancer stem cells through downregulating CBX4 expression and inactivating ERK …

Z Dou, F Lu, J Hu, H Wang, B Li, X Li - Biological Chemistry, 2023 - degruyter.com
Hepatocellular carcinoma (HCC) is the most common primary human liver malignancy with
high mortality. Liver cancer stem cells (CSCs) have been demonstrated to contribute to the …

miR-613 inhibits liver cancer stem cell expansion by regulating SOX9 pathway

B Li, D Liu, P Yang, HY Li, D Wang - Gene, 2019 - Elsevier
Liver cancer stem cells (CSCs) contribute to tumorigenesis, progression, drug resistance
and recurrence of hepatocellular carcinoma (HCC). However, the underlying mechanism for …

A novel regulatory loop miR-101/ANXA2/EGR1 mediates malignant characteristics of liver cancer stem cells

S Ma, J Cheng, H Wang, N Ding, F Zhou, R Ji… - …, 2021 - academic.oup.com
Increasing evidence suggests that liver cancer stem cells (LCSCs) are the cellular
determinants that promote tumor recurrence and metastases. Aberrantly expressed miRNAs …

Regulatory role of miRNA-1246 and Wnt/β-catenin pathway interaction in CD133+ liver cancer stem cells-driven hepatocellular carcinoma

S Chai, KY Ng, M Tong, ST Cheung, XY Guan, S Ma - Cancer Research, 2015 - AACR
Hepatocellular carcinoma (HCC), the main type of liver cancer in human, is one of the most
prevalent and deadly malignancies in the world. Despite advances in therapy, prognosis …

COL4A1, negatively regulated by XPD and miR-29a-3p, promotes cell proliferation, migration, invasion and epithelial–mesenchymal transition in liver cancer cells

H Zhang, Y Wang, H Ding - Clinical and Translational Oncology, 2021 - Springer
Objective Collagen type IV alpha 1 (COL4A1) exerts tumor-promoting functions in several
tumors. However, its role in liver cancer remains not fully understood. Hence, this study aims …

[HTML][HTML] MicroRNA-452 promotes stem-like cells of hepatocellular carcinoma by inhibiting Sox7 involving Wnt/β-catenin signaling pathway

Z Zheng, J Liu, Z Yang, L Wu, H Xie, C Jiang, B Lin… - Oncotarget, 2016 - ncbi.nlm.nih.gov
The decrease of microRNA-452 (miR-452) in gliomas promoted stem-like features and
tumorigenesis. However, the role of miR-452, especially in regulating cancer stem cells …

miR-219 regulates liver cancer stem cell expansion via E-cadherin pathway

A Si, L Wang, K Miao, R Zhang, H Ji, Z Lei, Z Cheng… - Cell Cycle, 2019 - Taylor & Francis
Liver cancer stem cells contribute to tumorigenesis, progression, recurrence and drug
resistance of hepatocellular carcinoma (HCC). However, the underlying mechanism for the …