Drugs that recapitulate aspects of the exercise adaptive response have the potential to
provide better treatment for diseases associated with physical inactivity. We previously …

Some gene deletions or mutations have little effect on metabolism and metabolic adaptation
because of redundancy and/or compensation in metabolic pathways. The mechanisms for …

Histone deacetylase (HDAC) has emerged as a new molecular target in the control of
obesity and type 2 diabetes. HDAC is an enzyme with well-known functions in the regulation …

Skeletal muscle is a highly adaptive organ that sustains continuous metabolic changes in
response to different functional demands. Healthy skeletal muscle can adjust fuel utilization …

Skeletal muscle is the largest metabolic organ in the human body and is able to rapidly
adapt to drastic changes during exercise. Histone acetyltransferases (HATs) and histone …

Skeletal muscle oxidative function and metabolic gene expression are co‐ordinately
downregulated in metabolic diseases such as insulin resistance, obesity and Type 2 …

Chromatin modifications are sensitive to environmental and nutritional stimuli. Abnormalities
in epigenetic regulation are associated with metabolic disorders such as obesity and …

Skeletal muscle plays a major role in controlling body mass and metabolism: it is the most
abundant tissue of the body and a major source of humoral factors; in addition, it is primarily …

Histone deacetylases (HDACs) play integral roles in many cardiovascular biological
processes ranging from transcriptional and translational regulation to protein stabilization …

Skeletal muscle adaptations to exercise confer many of the health benefits of physical
activity and occur partly through alterations in skeletal muscle gene expression. The exact …