Recent findings on chimeric antigen receptor (CAR)-engineered immune cell therapy in solid tumors and hematological malignancies
A Keshavarz, A Salehi, S Khosravi, Y Shariati… - Stem Cell Research & …, 2022 - Springer
Advancements in adoptive cell therapy over the last four decades have revealed various
new therapeutic strategies, such as chimeric antigen receptors (CARs), which are dedicated …
new therapeutic strategies, such as chimeric antigen receptors (CARs), which are dedicated …
Current progress of chimeric antigen receptor (CAR) T versus CAR NK cell for immunotherapy of solid tumors
Equipping cancer-fighting immune cells with chimeric antigen receptor (CAR) has gained
immense attention for cancer treatment. CAR-engineered T cells (CAR T cells) are the first …
immense attention for cancer treatment. CAR-engineered T cells (CAR T cells) are the first …
CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances
In the last decade, Chimeric Antigen Receptor (CAR)-T cell therapy has emerged as a
promising immunotherapeutic approach to fight cancers. This approach consists of …
promising immunotherapeutic approach to fight cancers. This approach consists of …
Efficacy, safety, and challenges of CAR T-cells in the treatment of solid tumors
Simple Summary Chimeric antigen receptor T cells (CAR T-cells) are engineered T cells that
target tumor-associated antigens. CAR T-cell therapy is a novel developed immunotherapy …
target tumor-associated antigens. CAR T-cell therapy is a novel developed immunotherapy …
CAR NK cell therapy in hematologic malignancies and solid tumors; obstacles and strategies to overcome the challenges
Adoptive cell treatment (ACT) utilizing chimeric antigen receptors (CAR) diverts the
specificity of safe cells against a target-specific antigen and portrays exceptional potential for …
specificity of safe cells against a target-specific antigen and portrays exceptional potential for …
Beyond CAR T cells: exploring alternative cell sources for CAR-like cellular therapies
CA Tsiverioti, A Gottschlich, S Theurich… - Biological …, 2024 - degruyter.com
Chimeric antigen receptor (CAR)-T cell therapy has led to remarkable clinical outcomes in
the treatment of hematological malignancies. However, challenges remain, such as limited …
the treatment of hematological malignancies. However, challenges remain, such as limited …
Hurdles of CAR-T cell-based cancer immunotherapy directed against solid tumors
BL Zhang, DY Qin, ZM Mo, Y Li, W Wei… - Science China Life …, 2016 - Springer
Recent reports on the impressive efficacy of chimeric antigen receptor (CAR)-modified T
cells against hematologic malignancies have inspired oncologists to extend these efforts for …
cells against hematologic malignancies have inspired oncologists to extend these efforts for …
CAR-NK as a rapidly developed and efficient immunotherapeutic strategy against cancer
M Włodarczyk, B Pyrzynska - Cancers, 2022 - mdpi.com
Simple Summary New approaches in adoptive immunotherapy using chimeric antigen
receptor (CAR)-modified cells have been developing very quickly in recent years, entering …
receptor (CAR)-modified cells have been developing very quickly in recent years, entering …
CAR-engineered NK cells; a promising therapeutic option for treatment of hematological malignancies
Adoptive cell therapy has received a great deal of interest in the treatment of advanced
cancers that are resistant to traditional therapy. The tremendous success of chimeric antigen …
cancers that are resistant to traditional therapy. The tremendous success of chimeric antigen …
CAR-based strategies beyond T lymphocytes: integrative opportunities for cancer adoptive immunotherapy
R Rotolo, V Leuci, C Donini, A Cykowska… - International Journal of …, 2019 - mdpi.com
Chimeric antigen receptor (CAR)-engineered T lymphocytes (CAR Ts) produced impressive
clinical results against selected hematological malignancies, but the extension of CAR T cell …
clinical results against selected hematological malignancies, but the extension of CAR T cell …
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