The kidney harbours different types of endothelia, each with specific structural and functional
characteristics. The glomerular endothelium, which is highly fenestrated and covered by a …

The glomerular endothelial cells are unique both in location and anatomy compared to most
other endothelial cells throughout the body. The absence of a diaphragm with retention of a …

The endothelium is considered to be the gatekeeper of the vessel wall, maintaining and
regulating vascular integrity. In patients with chronic kidney disease, protective endothelial …

Accumulating evidence indicates that the pathological changes of the endothelium may
contribute to the development of cardiovascular complications in chronic kidney disease …

Renal dysfunction and cardiovascular disorders affect each other adversely and worsen
existing pathophysiological conditions. These disorders are extremely diverse in terms of …

The kidney is comprised of heterogeneous cell populations that function together to perform
a number of tightly controlled, complex and interdependent processes. Renal endothelial …

Diabetic nephropathy is the leading cause of end-stage renal disease. Diabetes mellitus is
characterized by generalized endothelial dysfunction. However, recent data also …

Patients with chronic renal failure (CRF) have a 20-fold increased risk of cardiovascular
death compared to the general population, with sudden death, cardiac failure and …

More conclusive endothelium-specific, inducible transgenic mouse models are still lacking.
There are studies, however, showing that the glomerular cell components interact much …

Cardiovascular complications dominate the landscape of chronic kidney diseases (CKD).
Endothelial cell dysfunction (ECD) is a well-known culprit of cardiovascular morbidity and it …