Organoids—Preclinical Models of Disease An organoid is a three-dimensional construct
composed of multiple cell types that originates from stem cells through self-organization and …

Organoids are powerful systems to facilitate the study of individuals' disorders and
personalized treatments. This emerging technology has improved the chance of …

Organoids are 3D in vitro culture systems derived from self-organizing stem cells. They can
recapitulate the in vivo architecture, functionality, and genetic signature of original tissues …

Innumerable studies associated with cellular differentiation, tissue response and disease
modeling have been conducted in two-dimensional (2D) culture systems or animal models …

In vitro cell cultures are crucial research tools for modeling human development and
diseases. Although the conventional monolayer cell cultures have been widely used in the …

Cellular models have created opportunities to explore the characteristics of human diseases
through well-established protocols, while avoiding the ethical restrictions associated with …

Organoids derived from stem cells or tissues in culture can develop into structures that
resemble the in vivo anatomy and physiology of intact organs. Human organoid cultures …

Abstract 3D culture has allowed the initiation and expansion of organ-like structures, called
organoids, from either tissue-resident adult stem cells or pluripotent stem cells. Today …

Limitations of monolayer culture conditions have motivated scientists to explore new models
that can recapitulate the architecture and function of human organs more accurately. Recent …

Recent technical advances in the stem cell field have enabled the in vitro generation of
complex structures resembling whole organs termed organoids. Most of these approaches …