Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant

ECD Gonçalves, GM Baldasso, MA Bicca, RS Paes… - Molecules, 2020 - mdpi.com
Medicinal use of Cannabis sativa L. has an extensive history and it was essential in the
discovery of phytocannabinoids, including the Cannabis major psychoactive compound—Δ9 …

Phytocannabinoid Pharmacology: Medicinal Properties of Cannabis sativa Constituents Aside from the “Big Two”

PB Sampson - Journal of Natural Products, 2020 - ACS Publications
Plant-based therapies date back centuries. Cannabis sativa is one such plant that was used
medicinally up until the early part of the 20th century. Although rich in diverse and interesting …

Molecular pharmacology of phytocannabinoids

SE Turner, CM Williams, L Iversen… - … : unraveling the complex …, 2017 - Springer
Cannabis sativa has been used for recreational, therapeutic and other uses for thousands of
years. The plant contains more than 120 C 21 terpenophenolic constituents named …

Pharmacological data of cannabidiol-and cannabigerol-type phytocannabinoids acting on cannabinoid CB1, CB2 and CB1/CB2 heteromer receptors

G Navarro, K Varani, A Lillo, F Vincenzi… - Pharmacological …, 2020 - Elsevier
Background Recent approved medicines whose active principles are Δ 9
Tetrahidrocannabinol (Δ 9-THC) and/or cannabidiol (CBD) open novel perspectives for …

Non-Cannabinoid Metabolites of Cannabis sativa L. with Therapeutic Potential

H Lowe, B Steele, J Bryant, N Toyang, W Ngwa - Plants, 2021 - mdpi.com
The cannabis plant (Cannabis sativa L.) produces an estimated 545 chemical compounds of
different biogenetic classes. In addition to economic value, many of these phytochemicals …

Pharmacological potential of varinic-, minor-, and acidic phytocannabinoids

R Franco, R Rivas-Santisteban, I Reyes-Resina… - Pharmacological …, 2020 - Elsevier
While natural Δ 9-tetrahidrocannabinol (Δ 9 THC), cannabidiol (CBD), and their therapeutic
potential have been extensively researched, some cannabinoids have been less extensively …

In vitro and in vivo pharmacological activity of minor cannabinoids isolated from Cannabis sativa

A Zagzoog, KA Mohamed, HJJ Kim, ED Kim… - Scientific Reports, 2020 - nature.com
The Cannabis sativa plant contains more than 120 cannabinoids. With the exceptions of∆ 9-
tetrahydrocannabinol (∆ 9-THC) and cannabidiol (CBD), comparatively little is known about …

Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb

AA Izzo, F Borrelli, R Capasso, V Di Marzo… - Trends in …, 2009 - cell.com
Δ 9-tetrahydrocannabinol binds cannabinoid (CB 1 and CB 2) receptors, which are activated
by endogenous compounds (endocannabinoids) and are involved in a wide range of …

Cannabis pharmacology: the usual suspects and a few promising leads

EB Russo, J Marcu - Advances in pharmacology, 2017 - Elsevier
The golden age of cannabis pharmacology began in the 1960s as Raphael Mechoulam and
his colleagues in Israel isolated and synthesized cannabidiol, tetrahydrocannabinol, and …

Phytocannabinoids beyond the Cannabis plant – do they exist?

J Gertsch, RG Pertwee… - British journal of …, 2010 - Wiley Online Library
It is intriguing that during human cultural evolution man has detected plant natural products
that appear to target key protein receptors of important physiological systems rather …