Ligand‐installed nanocarriers toward precision therapy

P Mi, H Cabral, K Kataoka - Advanced Materials, 2020 - Wiley Online Library
Abstract Development of drug‐delivery systems that selectively target neoplastic cells has
been a major goal of nanomedicine. One major strategy for achieving this milestone is to …

[HTML][HTML] Progress and challenges towards targeted delivery of cancer therapeutics

D Rosenblum, N Joshi, W Tao, JM Karp… - Nature communications, 2018 - nature.com
Targeted delivery approaches for cancer therapeutics have shown a steep rise over the past
few decades. However, compared to the plethora of successful pre-clinical studies, only 15 …

Extracellularly activated nanocarriers: a new paradigm of tumor targeted drug delivery

E Gullotti, Y Yeo - Molecular pharmaceutics, 2009 - ACS Publications
One of the main goals of nanomedicine is to develop a nanocarrier that can selectively
deliver anticancer drugs to the targeted tumors. Extensive efforts have resulted in several …

Actively targeted nanocarriers for drug delivery to cancer cells

S Biffi, R Voltan, B Bortot, G Zauli… - Expert opinion on drug …, 2019 - Taylor & Francis
Introduction: Progressive breakthroughs in nanomedicine have been instrumental for the
clinical translation of actively targeted drug-delivery approaches. Besides storing large …

Development of highly efficient nanocarrier-mediated delivery approaches for cancer therapy

K Jeong, CS Kang, Y Kim, YD Lee, IC Kwon, S Kim - Cancer letters, 2016 - Elsevier
Nanocarriers (NCs) are a group of nano-sized vehicles devised to deliver drugs to targeted
malignant tissues or organs that provide remarkably improved targeting efficiency and …

Recent advances in targeted nanomedicine as promising antitumor therapeutics

S Hejmady, R Pradhan, A Alexander, M Agrawal… - Drug discovery today, 2020 - Elsevier
Highlights•Nanocarriers with the ability to target tumors are being increasingly explored.•
Nanomedicine aid in maintaining a balance between efficacy and toxicity.•Recent advances …

Engineering the assemblies of biomaterial nanocarriers for delivery of multiple theranostic agents with enhanced antitumor efficacy.

H Wang, Y Wu, R Zhao, G Nie - Advanced Materials (Deerfield …, 2013 - europepmc.org
The rapid development of nanotechnology holds great promise for revolutionizing the
current landscape of tumor drug delivery. However, one of the biggest challenges is …

Challenges in design of translational nanocarriers

Q Sun, M Radosz, Y Shen - Journal of controlled release, 2012 - Elsevier
Cancer drug delivery achieving high therapeutic efficacy and low side effects requires a
nanocarrier to tightly retain the drug, efficiently reach the tumor, then quickly enter the tumor …

[HTML][HTML] Tumour-targeted nanomedicines: principles and practice

T Lammers, WE Hennink, G Storm - British journal of cancer, 2008 - nature.com
Drug targeting systems are nanometre-sized carrier materials designed for improving the
biodistribution of systemically applied (chemo) therapeutics. Various different tumour …

Ligand-based targeted therapy for cancer tissue

M Das, C Mohanty, SK Sahoo - Expert opinion on drug delivery, 2009 - Taylor & Francis
Background: Limited accessibility of drugs to the tumor tissues, the requirement of high
doses, intolerable cytotoxicity, the development of multiple drug resistance and non-specific …