Age-and gender-related differences in ischemia/reperfusion injury and cardioprotection: effects of diazoxide
JD McCully, Y Toyoda, H Wakiyama, AJ Rousou… - The Annals of thoracic …, 2006 - Elsevier
BACKGROUND: Recent studies have demonstrated that aging is associated with reduced
tolerance to ischemia and that the aged (not senescent) female heart has greater …
tolerance to ischemia and that the aged (not senescent) female heart has greater …
Age-and gender-related differences in mitochondrial oxygen consumption and calcium with cardioplegia and diazoxide
JD McCully, AJ Rousou, RA Parker… - The Annals of thoracic …, 2007 - Elsevier
BACKGROUND: We have recently shown that the cardioprotection afforded by cardioplegia
is affected by age and gender and is less effective in the aged female rabbit heart compared …
is affected by age and gender and is less effective in the aged female rabbit heart compared …
Aging increases ischemia-reperfusion injury in the isolated, buffer-perfused heart
EJ Lesnefsky, DS Gallo, J Ye… - The Journal of …, 1994 - translationalres.com
Survival after acute myocardial infarction is decreased in elderly patients as compared with
the overall adult population. Although several cardiac and noncardiac causes could …
the overall adult population. Although several cardiac and noncardiac causes could …
Differences in ischemic damage between young and old hearts—effects of blood cardioplegia
A Böning, S Rohrbach, L Kohlhepp, M Heep… - Experimental …, 2015 - Elsevier
Objective Senescent patients exhibit an elevated perioperative risk for cardiac dysfunction,
hemodynamic depression and subsequent cardiac death compared to young patients …
hemodynamic depression and subsequent cardiac death compared to young patients …
Ischemia-reperfusion in the adult mouse heart: Influence of age☆
G Azhar, W Gao, L Liu, JY Wei - Experimental gerontology, 1999 - Elsevier
Age-related changes in the mouse heart after ischemia-reperfusion have not been well
characterized. To test the hypothesis that advanced age was associated with increased …
characterized. To test the hypothesis that advanced age was associated with increased …
[HTML][HTML] The aging human myocardium: tolerance to ischemia and responsiveness to ischemic preconditioning
M Loubani, S Ghosh, M Galiñanes - The Journal of thoracic and …, 2003 - Elsevier
BACKGROUND: Increasing age has been recognized as a cause for adverse prognosis in
the setting of myocardial infarction, coronary angioplasty, and cardiac surgery. This is …
the setting of myocardial infarction, coronary angioplasty, and cardiac surgery. This is …
[HTML][HTML] Cardioprotection and ageing
YH Shim - Korean journal of anesthesiology, 2010 - synapse.koreamed.org
With an increase in the elderly population and an increase in the prevalence of age-related
cardiovascular disease, anesthesiologists are increasingly being faced with elderly patients …
cardiovascular disease, anesthesiologists are increasingly being faced with elderly patients …
[HTML][HTML] Ischemia and reperfusion injury following cardioplegic arrest is attenuated by age and testosterone deficiency in male but not female mice
A Ghimire, ES Bisset, SE Howlett - Biology of sex Differences, 2019 - Springer
Background Cardiovascular disease increases with age in both sexes. Treatment can
require cardiac surgery, where the hearts are pre-treated with protective cardioplegic …
require cardiac surgery, where the hearts are pre-treated with protective cardioplegic …
Age-related difference in myocardial function and inflammation in a rat model of myocardial ischemia–reperfusion
P Liu, B Xu, TA Cavalieri, CE Hock - Cardiovascular research, 2002 - academic.oup.com
Objective: Aging is associated with a reduced tolerance to myocardial ischemia reperfusion
injury when compared to the young adult. However, there is very little information in the …
injury when compared to the young adult. However, there is very little information in the …
Protecting the aged heart during cardiac surgery: single-dose del Nido cardioplegia is superior to multi-dose del Nido cardioplegia in isolated rat hearts
A Govindapillai, C Hancock Friesen… - Perfusion, 2016 - journals.sagepub.com
Background: Aged hearts are particularly vulnerable to reperfusion injury. We recently
showed that single-dose del Nido cardioplegia was superior to 'standard'multi-dose 4: 1 …
showed that single-dose del Nido cardioplegia was superior to 'standard'multi-dose 4: 1 …