The loss of estrogen (E2) initiates a rapid phase of bone loss leading to osteoporosis in one‐
half of postmenopausal women, but the mechanism is not fully understood. Here, we show …

Increased production of tumor necrosis factor α (TNF) in the bone marrow (BM) in response
to both oxidative stress and T cell activation contributes to the bone loss induced by …

Presently the relationship between CD28, biological marker of senescence, and
ovariectomy is not well understood. We show that ovariectomy leads to CD28 loss on T cells …

Background The role of T helper (Th) 17 cells in autoimmune diseases has been extensively
studied recently, but its function in oestrogen‐deficient osteoporosis remains undefined. This …

Osteoporosis is a serious clinical problem that often follows the accelerated bone loss that
occurs after the estrogen withdrawal of menopause. In order to better understand the …

Post‐menopausal osteoporosis is considered to be an inflammatory process, in which
numerous pro‐inflammatory and T‐cell‐derived cytokines play a bone‐destructive role. IL …

Osteoporosis is the most prevalent metabolic bone disease that affects half the women in the
sixth and seventh decade of life. Osteoporosis is characterized by uncoupled bone …

Abstract Interleukin (IL)-17A is a well-described mediator of bone resorption in inflammatory
diseases, and postmenopausal osteoporosis is associated with increased serum levels of IL …

Estrogen (E) deficiency leads to an expansion of the pool of tumor necrosis factor (TNF)-
producing T cells through an IFN-γ-dependent pathway that results in increased levels of the …

Th17 cells produce IL-17, and the latter promotes bone loss in collagen-induced arthritis in
mice. Blocking IL-17 action in mouse model of rheumatoid arthritis reduces disease …