[HTML][HTML] Recent progress in functional modification and crosslinking of bioprosthetic heart valves

C Zheng, L Yang, Y Wang - Regenerative Biomaterials, 2024 - academic.oup.com
Valvular heart disease (VHD), clinically manifested as stenosis and regurgitation of native
heart valve, is one of the most prevalent cardiovascular diseases with high mortality. Heart …

A versatile modification strategy for functional non-glutaraldehyde cross-linked bioprosthetic heart valves with enhanced anticoagulant, anticalcification and …

T Yu, H Pu, X Chen, Q Kong, C Chen, G Li, Q Jiang… - Acta Biomaterialia, 2023 - Elsevier
Valvular heart disease is a major threat to human health and transcatheter heart valve
replacement (THVR) has emerged as the primary treatment option for severe heart valve …

Radical polymerization-crosslinking method for improving extracellular matrix stability in bioprosthetic heart valves with reduced potential for calcification and …

G Guo, L Jin, W Jin, L Chen, Y Lei, Y Wang - Acta biomaterialia, 2018 - Elsevier
In recent years, the number of heart valve replacements has multiplied with valve diseases
because of aging populations and the surge in rheumatic heart disease in young people …

[HTML][HTML] Hybrid heart valves with VEGF-loaded zwitterionic hydrogel coating for improved anti-calcification and re-endothelialization

Q Tong, A Sun, Z Wang, T Li, X He, Y Qian, Z Qian - Materials Today Bio, 2022 - Elsevier
With the aging of the population in worldwide, valvular heart disease has become one of the
most prominent life-threatening diseases in human health, and heart valve replacement …

A functionalized biological heart valve by double bond crosslinking with enhanced biocompatibility and antithrombogenicity

C Zheng, D Kuang, K Ding, X Huang, H Fan… - Journal of Materials …, 2022 - pubs.rsc.org
With the advancement of minimally invasive interventional therapy, biological heart valves
(BHVs) have been extensively used in clinics. However, BHVs are generally prone to …

Crosslinking porcine aortic valve by radical polymerization for the preparation of BHVs with improved cytocompatibility, mild immune response, and reduced …

L Xu, F Yang, Y Ge, G Guo… - Journal of Biomaterials …, 2021 - journals.sagepub.com
Over one million artificial heart valve transplantations are performed each year due to
valvular stenosis or regurgitation. Among them, bioprosthetic heart valves (BHVs) are …

Recent Advances in the Modification and Improvement of Bioprosthetic Heart Valves

Q Tong, J Cai, Z Wang, Y Sun, X Liang, Q Xu… - Small, 2024 - Wiley Online Library
Valvular heart disease (VHD) has become a burden and a growing public health problem in
humans, causing significant morbidity and mortality worldwide. An increasing number of …

A PEGylation method of fabricating bioprosthetic heart valves based on glutaraldehyde and 2-amino-4-pentenoic acid co-crosslinking with improved …

K Ding, C Zheng, X Huang, S Zhang, M Li, Y Lei… - Acta Biomaterialia, 2022 - Elsevier
With the development of diagnostic techniques, the incidence of bioprosthetic heart valve
thrombosis (BHVT) is found to be seriously underestimated. Developing bioprosthetic heart …

[HTML][HTML] The hybrid crosslinking method improved the stability and anti-calcification properties of the bioprosthetic heart valves

Y Liu, Z Wu, C Chen, T Lu, M Song, X Qi… - … in Bioengineering and …, 2022 - frontiersin.org
The bioprosthetic heart valves (BHVs) are the best option for the treatment of valvular heart
disease. Glutaraldehyde (Glut) is commonly used as the golden standard reagent for the …

Dual-crosslinked bioprosthetic heart valves prepared by glutaraldehyde crosslinked pericardium and poly-2-hydroxyethyl methacrylate exhibited improved …

X Huang, C Zheng, K Ding, S Zhang, Y Lei, Q Wei… - Acta Biomaterialia, 2022 - Elsevier
Bioprosthetic heart valves (BHVs) have been widely used due to the revolutionary
transcatheter aortic valve replacement (TAVR) techniques but suffer from a limited lifespan …