TWO abnormal high oxygen affinity haemoglobins have been studied for their ability to
inhibit the polymerization of deoxy‐Hb S. They were used as models to predict the effect of …

In an attempt to predict the likelihood of successfully treating sickle cell disease by
increasing haemoglobin S (Hb S) oxygen affinity, two liganded derivatives of Hb S have …

There is considerable evidence that deoxyhemoglobin S molecules tend to aggregate with
formation of polymers, but the nature of the binding sites between adjacent hemoglobin …

The effect of the concentration of haemoglobin S (Hb S) on its oxygen‐dissociation
properties was studied using either reconstituted Hb‐S cells of different mean corpuscular …

The doubly substituted variant Hb S‐Antilles (β6 Glu→ Val, β3 Val→ Ile) produces sickling in
heterozygous carriers. The Csat value for pure deoxyHb S‐Antilles is nearly half that of …

The decrease in oxygen affinity with increasing hemoglobin concentration, which occurs in
solutions of pure hemoglobin S, can be used to determine the minimum concentration at …

The effectiveness of cyanate as an in vitro inhibitor of sickling'and the preliminary evidence
of its clinical usefulness when administered via an extracorporeal route” have stimulated the …

Sickle cell disease (SCD) continues to cause significant morbidity, mortality and healthcare
disparities. Despite considerable progress in understanding the underlying pathophysiology …

Hemoglobin S polymerization is markedly dependent on intracellular hemoglobin
concentration. In the studies presented here, sickle RBC were subjected to a transient …

The role of Asp-beta 73 on the surface hydrophobicity and solubility of hemoglobin was
studied using Hb A, Hb S, Hb C Harlem (alpha 2 beta 2Val-6, Asn-73), and Hb Korle Bu …