Purpose Anal fissure is caused by a pathological contraction of the internal anal sphincter.
Lateral internal sphincterotomy remains the gold standard for the treatment of fissure …

Objective To investigate the effects of two different dosage regimens of botulinum toxin to
induce healing in patients with idiopathic anal fissure. Summary Background Data Chronic …

PURPOSE: Botulinum toxin injection into the internal anal sphincter has been shown to be
an effective treatment for chronic anal fissure. A randomized, prospective trial was …

Background. Botulinum toxin induces healing in patients with idiopathic anal fissures.
Methods. One hundred-fifty patients with posterior anal fissures were treated with botulinum …

Background: Botulinum toxin induces healing in patients with idiopathic anal fissure.
Methods: Fifty patients affected by posterior anal fissure were treated with 20 units of …

Abstract Background/Aims: The aim of this study was to evaluate the effectiveness of
botulinum toxin for the treatment of uncomplicated dorsal chronic idiopathic anal fissure …

Objectives The aim of the study was to evaluate the effect of botulinum toxin (BT) injection on
fissure healing in the treatment of chronic anal fissure (CAF) in outpatient conditions without …

Background Chronic anal fissure is a tear in the lower half of the anal canal that is
maintained by contraction of the internal anal sphincter. Sphincterotomy, the most widely …

Background and aim: Hypertonicity of internal anal sphincter plays a major role in the
persistence of chronic anal fissure. Botulinum toxin could induce internal anal sphincter …

Background & Aims: Botulinum toxin is an effective treatment in idiopathic chronic anal
fissure, but the long-term outcome after healing is not well documented. We analyzed the …