Pediatric diabetic ketoacidosis, fluid therapy, and cerebral injury: the design of a factorial randomized controlled trial

NS Glaser, S Ghetti, TC Casper, JM Dean… - Pediatric …, 2013 - Wiley Online Library
Treatment protocols for pediatric diabetic ketoacidosis (DKA) vary considerably among
centers in the USA and worldwide. The optimal protocol for intravenous (IV) fluid …

Clinical trial of fluid infusion rates for pediatric diabetic ketoacidosis

N Kuppermann, S Ghetti, JE Schunk… - … England Journal of …, 2018 - Mass Medical Soc
Background Diabetic ketoacidosis in children may cause brain injuries ranging from mild to
severe. Whether intravenous fluids contribute to these injuries has been debated for …

Emergency medicine myths: cerebral edema in pediatric diabetic ketoacidosis and intravenous fluids

B Long, A Koyfman - The Journal of emergency medicine, 2017 - Elsevier
Background Pediatric diabetic ketoacidosis (DKA) is a disease associated with several
complications that can be severe. One complication includes cerebral edema (CE), and …

Fluid management in pediatric patients with DKA and rates of suspected clinical cerebral edema

DS Hsia, SG Tarai, A Alimi, JA Coss‐Bu… - Pediatric …, 2015 - Wiley Online Library
Objective To compare outcomes of diabetic ketoacidosis (DKA) 6 yrs before and 6 yrs after
changing rehydration fluids from ½ normal saline to Lactated Ringer's and decreasing the …

Low morbidity and mortality in children with diabetic ketoacidosis treated with isotonic fluids

PC White, BA Dickson - The Journal of pediatrics, 2013 - Elsevier
Objective To assess current rates of complications of diabetic ketoacidosis (DKA),
particularly cerebral edema, in a large tertiary-care pediatric hospital with a consistent …

Fluid therapy for pediatric patients with diabetic ketoacidosis: current perspectives

M Jayashree, V Williams, R Iyer - Diabetes, Metabolic Syndrome …, 2019 - Taylor & Francis
Diabetic ketoacidosis (DKA) is a preventable life-threatening complication of type 1
diabetes. Fluids form a crucial component of DKA therapy, goals being the restoration of …

Diabetic ketoacidosis fluid management in children: systematic review and meta-analyses

AA Hamud, K Mudawi, A Shamekh, A Kadri… - Archives of Disease in …, 2022 - adc.bmj.com
Importance Diabetic ketoacidosis (DKA) is a serious complication of type 1 diabetes mellitus,
which may lead to significant morbidity and mortality. Objectives To compare the safety and …

Evidence-based emergency medicine/critically appraised topic. Is fluid therapy associated with cerebral edema in children with diabetic ketoacidosis?

J Hom, R Sinert - Annals of Emergency Medicine, 2008 - europepmc.org
Study objective Diabetic ketoacidosis is the most common cause of morbidity and mortality
in children with type I diabetes mellitus, and cerebral edema is the leading cause of pediatric …

An 18‐yr prospective study of pediatric diabetic ketoacidosis: an approach to minimizing the risk of brain herniation during treatment

I Fiordalisi, WE Novotny, D Holbert, L Finberg… - Pediatric …, 2007 - Wiley Online Library
Background: During the late 1900s, raised intracranial pressure (ICP) during treatment of
pediatric diabetic ketoacidosis (DKA) surfaced as the most important cause of morbidity and …

Serum sodium concentration and mental status in children with diabetic ketoacidosis

NS Glaser, MJ Stoner, A Garro, S Baird, SR Myers… - …, 2021 - publications.aap.org
OBJECTIVES Diabetic ketoacidosis (DKA) is typically characterized by low or low-normal
serum sodium concentrations, which rise as hyperglycemia resolves. In retrospective …