Under steady-state conditions, the immune system is poised to sense and respond to the
microbiota. As such, immunity to the microbiota, including T cell responses, is expected to …

Abstract Background Psoriasis impacts 1–3% of the world's population and is characterized
by hyper-proliferation of keratinocytes and increased inflammation. At the molecular level …

Psoriasis is a chronic inflammatory skin disease in which Th17 cells play a crucial role.
Since indigenous gut microbiota influences the development and reactivity of immune cells …

Psoriasis is a multifactorial immune-mediated disease. The highly effective and eligible
treatment for psoriasis is limited, for its specific pathogenesis is incompletely elucidated …

Despite recent advances in understanding microbial diversity in skin homeostasis, the
relevance of microbial dysbiosis in inflammatory disease is poorly understood. Here we …

Psoriatic patients have altered microbiota, both in the intestine and on the skin. It is not clear,
however, whether this is a cause or consequence of the disease. In this study, using an …

Psoriasis is driven by focal disruptions of the immune-homeostasis in human skin. Local
relapse following cessation of therapy is common and unpredictable, which complicates …

Psoriasis is an inflammatory skin disease affecting∼ 2% of the world's population, but the
aetiology remains incompletely understood. Recently, microbiota have been shown to …

With advancement in human microbiome research, an increasing number of scientific
evidences have endorsed the key role of both gut and skin microbiota in the pathogenesis of …

Background The skin harbors complex communities of resident microorganisms, yet little is
known of their physiological roles and the molecular mechanisms that mediate cutaneous …