Zinc promotes osteoblast differentiation in human mesenchymal stem cells via activation of the cAMP-PKA-CREB signaling pathway

KH Park, Y Choi, DS Yoon, KM Lee, D Kim… - Stem cells and …, 2018 - liebertpub.com
The crucial trace element zinc stimulates osteogenesis in vitro and in vivo. However, the
pathways mediating these effects remain poorly understood. This study aimed to investigate …

Zinc deficiency suppresses matrix mineralization and retards osteogenesis transiently with catch-up possibly through Runx 2 modulation

IS Kwun, YE Cho, RAR Lomeda, HI Shin, JY Choi… - Bone, 2010 - Elsevier
A characteristic sign of zinc deficiency is retarded skeletal growth, but the role of zinc in
osteoblasts is not well understood. Two major events for bone formation include osteoblast …

[HTML][HTML] Zinc may increase bone formation through stimulating cell proliferation, alkaline phosphatase activity and collagen synthesis in osteoblastic MC3T3-E1 cells

HJ Seo, YE Cho, T Kim, HI Shin… - Nutrition research and …, 2010 - synapse.koreamed.org
Zinc is an essential trace element required for bone formation, however not much has been
clarified yet for its role in osteoblast. We hypothesized that zinc would increase osteogenetic …

The role of zinc in bone tissue health and regeneration—a review

M Molenda, J Kolmas - Biological Trace Element Research, 2023 - Springer
Zinc is a micronutrient of key importance for human health. An increasing number of studies
indicate that zinc plays a significant role in bone tissue's normal development and …

[HTML][HTML] Zinc as a therapeutic agent in bone regeneration

JP O'Connor, D Kanjilal, M Teitelbaum, SS Lin… - Materials, 2020 - mdpi.com
Zinc is an essential mineral that is required for normal skeletal growth and bone
homeostasis. Furthermore, zinc appears to be able to promote bone regeneration. However …

Zinc supplements and bone health: The role of the RANKL-RANK axis as a therapeutic target

N Amin, CCT Clark, M Taghizadeh… - Journal of Trace Elements …, 2020 - Elsevier
Background To this day, empirical data suggests that zinc has important roles in matrix
synthesis, bone turnover, and mineralization and its beneficial effects on bone could be …

Zinc upregulates the expression of osteoprotegerin in mouse osteoblasts MC3T3-E1 through PKC/MAPK pathways

D Liang, M Yang, B Guo, J Cao, L Yang… - Biological trace element …, 2012 - Springer
Zinc is an essential element for bone formation; however, its role in osteoblast has not been
well understood. In the present study, we hypothesized that zinc could increase …

Eluted zinc ions stimulate osteoblast differentiation and mineralization in human dental pulp stem cells for bone tissue engineering

K Yusa, O Yamamoto, M Iino, H Takano, M Fukuda… - Archives of oral …, 2016 - Elsevier
Objective Zinc is an essential element for proliferation, differentiation and survival in various
cell types. In a previous study, we found that zinc ions released from zinc-modified titanium …

Osteoblast-mediated effects of zinc on isolated rat osteoclasts: inhibition of bone resorption and enhancement of osteoclast number

WR Holloway, FM Collier, RE Herbst, JM Hodge… - Bone, 1996 - Elsevier
Zinc is an important element in biology yet little is understood of its role in bone cell
metabolism and function. This study examined the effects of zinc on osteoclast (OC) function …

Zirconium ions up-regulate the BMP/SMAD signaling pathway and promote the proliferation and differentiation of human osteoblasts

Y Chen, SI Roohani-Esfahani, ZF Lu, H Zreiqat… - PLoS …, 2015 - journals.plos.org
Zirconium (Zr) is an element commonly used in dental and orthopedic implants either as
zirconia (ZrO2) or in metal alloys. It can also be incorporated into calcium silicate-based …