In this work, a dual recognized CRISPR/Cas12a system has been proposed, in which the
activation chain is cleverly divided into two parts that can serve for precise dual target …

Accurate identification of Staphylococcus aureus (S. aureus) is crucial for food safety and
clinical diagnosis. Particularly, identifying drug-resistant strains guides effective treatment …

The severity of foodborne diseases caused by foods contaminated by pathogens or their
toxins creates an urgent need for the development of specific and sensitive method for …

Rapid and sensitive detection of pathogenic bacteria is crucial for disease prevention and
control. The CRISPR/Cas12a system with the DNA cleavage capability holds promise in …

Staphylococcus aureus is one of the main pathogens causing hospital and community-
acquired infections, in particular, infections caused by methicillin-resistant Staphylococcus …

Methicillin-resistant Staphylococcus aureus (MRSA) strains are prevalent foodborne
superbugs and pose significant pathogens for both humans and animals. The sensitive and …

Early-diagnosis and treatments of skin and soft tissue infections remain a huge challenge
due to the difficulties in the detection of trace amounts of bacteria. We develop here a novel …

Detection of methicillin-resistant Staphylococcus aureus (MRSA) with superior accuracy,
timeliness, and simplicity is highly valuable in clinical diagnosis and food safety. In this …

In this study, a hydrazone chemistry-mediated clustered regularly interspaced palindromic
repeats (CRISPR)/CRISPR-associated protein 12a (Cas12a) system has been proposed for …

CRISPR-Cas systems have been employed to detect a large variety of pathogenic
microorganisms by simply changing the guide RNA sequence. However, these platforms …