Although efficacy of combined histone deacetylase (HDAC) inhibitors and conventional
photon radiotherapy is being tested in clinical trials, their combined effect with proton beam …

Epigenetic modulation by histone deacetylase (HDAC) inhibitors is an attractive anti-cancer
strategy for diverse hematological and solid cancers. Herein, we explored the relative …

Recent studies have highlighted the implications of genetic variations in the relative
biological effectiveness (RBE) of proton beam irradiation over conventional X-ray irradiation …

Proton radiotherapy has been implemented into the standard-of-care for cancer patients
within recent years. However, experimental studies investigating cellular and molecular …

A proton beam therapy is considered the next generation radio-therapeutic tool for liver
cancer treatments. However, its effect on metastasis has not been fully elucidated. Herein …

Histone deacetylase inhibitors (HDI) have shown promise as candidate radiosensitizers for
many types of cancers, including prostate cancer. However, the mechanisms of action are …

Radiation therapy is a major treatment in hepatocellular carcinoma (HCC). Yet, this
treatment is ineffective in HCC due to lack of radiosensitivity. For this reason, we examined …

Background Radiotherapy (RT) is one of the major therapeutic approaches to hepatocellular
carcinoma (HCC). Ionizing radiation (IR) inducing the generation of reactive oxygen species …

Background and purpose Non-homologous end-joining (NHEJ) and homologous
recombination (HR) contribute to the repair of irradiation-induced DNA double-strand breaks …

Background A promising avenue for cancer treatment is exacerbating the deregulation of the
DNA repair machinery that would normally protect the genome. To address the applicability …