Tanshinol A ameliorates triton‐1339W‐induced hyperlipidemia and liver injury in C57bl/6J mice by regulating mRNA expression of lipemic‐oxidative injury genes

Y Li, Y Chen, X Huang, D Huang, H Gan, N Yao, Z Hu… - Lipids, 2020 - Wiley Online Library
Tanshinol A, which is derived from a traditional Chinese herbal Radix Salviae Miltiorrhizae
is indicative of a hypolipidemic candidate. Therefore, we aim to validate its hypolipidemic …

Tanshinone IIA downregulates lipogenic gene expression and attenuates lipid accumulation through the modulation of LXRα/SREBP1 pathway in HepG2 cells

WY Gao, PY Chen, HJ Hsu, CY Lin, MJ Wu, JH Yen - Biomedicines, 2021 - mdpi.com
Abnormal and excessive accumulation of lipid droplets within hepatic cells is the main
feature of steatosis and nonalcoholic fatty liver disease (NAFLD) or metabolic-associated …

[HTML][HTML] Protective effect of Hedansanqi Tiaozhi Tang against non-alcoholic fatty liver disease in vitro and in vivo through activating Nrf2/HO-1 antioxidant signaling …

M Qiu, F Xiao, T Wang, S Piao, W Zhao, S Shao, M Yan… - Phytomedicine, 2020 - Elsevier
Abstract Background Hedansanqi Tiaozhi Tang extract (HTT) consists of Notoginseng,
Danshen, Hawthorn and Lotus leaf from traditional Chinese medicine, which has significant …

Tanshinone IIA ameliorates nonalcoholic steatohepatitis in mice by modulating neutrophil extracellular traps and hepatocyte apoptosis

L Xu, X Liu, T Jia, Y Sun, Y Du, S Wei… - Evidence‐Based …, 2022 - Wiley Online Library
Salvia miltiorrhiza Bunge, a traditional Chinese medicine, is widely used in the treatment of
a variety of diseases and syndromes. Tanshinone IIA (TIIA), a phenanthrenequinone‐class …

Tanshinone IIA protects against triptolide-induced liver injury via Nrf2/ARE activation

CW Guan, J Jin, J Li, ZX Zhao… - Yao xue xue bao= Acta …, 2013 - europepmc.org
The aim of this study is to investigate the protection effect of tanshinone IIA (Tan) against
triptolide (TP)-induced liver injury and the mechanisms involved. Acute liver injury was …

4‐Octyl Itaconate Prevents Free Fatty Acid‐Induced Lipid Metabolism Disorder through Activating Nrf2‐AMPK Signaling Pathway in Hepatocytes

X Chu, L Li, W Yan, H Ma - Oxidative medicine and cellular …, 2022 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD), characterized with oxidative stress and hepatic
steatosis, is a serious threat to human health. As a specific activator of nuclear factor E2 …

Sanghuangporus vaninii extract ameliorates hyperlipidemia in rats by mechanisms identified with transcriptome analysis

N Gao, Y Liu, G Liu, B Liu, Y Cheng - Food Science & Nutrition, 2024 - Wiley Online Library
The increasing incidence of hyperlipidemia is a serious threat to public health. The
development of effective and safe lipid‐lowering drugs with few side effects is necessary …

Wogonoside improves high-fat diet-induced hyperlipidemia and aortic injury in ApoE-/-mice by upregulating SIRT1 expression

S Lin, Y Zhu, R Chen, T Hu, K Wang - … Assurance and Safety of Crops & …, 2023 - qascf.com
This study aimed to evaluate the effect of Wogonoside (Wog), a flavonoid monomer, on
hyperlipidemia and explore its possible mechanisms. APOE-/-mice were used to establish …

Triptriolide alleviates lipopolysaccharide-induced liver injury by Nrf2 and NF-κB signaling pathways

YQ Yang, XT Yan, K Wang, RM Tian, ZY Lu… - Frontiers in …, 2018 - frontiersin.org
Nrf2 (Nuclear Factor Erythroid 2 Related Factor 2) transcription factor not only regulates
oxidative stress response, but also represses inflammation by regulating cytokines …

Effects of Tanshinone IIA on the modulation of miR‑33a and the SREBP‑2/Pcsk9 signaling pathway in hyperlipidemic rats

L Jia, N Song, G Yang, Y Ma, X Li… - Molecular …, 2016 - spandidos-publications.com
Tanshinone IIA is the active compound isolated from Salvia miltiorrhiza bunge, which is a
traditional Chinese medicine known as Danshen. The aim of the present study was to …