[HTML][HTML] Fine-mapping genomic loci refines bipolar disorder risk genes

M Koromina, A Ravi, G Panagiotaropoulou… - medRxiv, 2024 - ncbi.nlm.nih.gov
Bipolar disorder (BD) is a heritable mental illness with complex etiology. While the largest
published genome-wide association study identified 64 BD risk loci, the causal SNPs and …

Functional genomic analysis delineates regulatory mechanisms of GWAS-identified bipolar disorder risk variants

R Chen, Z Yang, J Liu, X Cai, Y Huo, Z Zhang, M Li… - Genome Medicine, 2022 - Springer
Background Genome-wide association studies (GWASs) have identified multiple risk loci for
bipolar disorder (BD). However, pinpointing functional (or causal) variants in the reported …

Integrative analyses prioritize GNL3 as a risk gene for bipolar disorder

Q Meng, L Wang, R Dai, J Wang, Z Ren, S Liu… - Molecular …, 2020 - nature.com
Genome-wide association studies (GWASs) have identified numerous single nucleotide
polymorphisms (SNPs) associated with bipolar disorder (BD), but what the causal variants …

Gene set enrichment analysis and expression pattern exploration implicate an involvement of neurodevelopmental processes in bipolar disorder

TW Mühleisen, CS Reinbold, AJ Forstner… - Journal of affective …, 2018 - Elsevier
Background Bipolar disorder (BD) is a common and highly heritable disorder of mood.
Genome-wide association studies (GWAS) have identified several independent …

Epigenetic element-based transcriptome-wide association study identifies novel genes for bipolar disorder

S Yao, H Wu, TT Liu, JH Wang, JM Ding… - Schizophrenia …, 2021 - academic.oup.com
Since the bipolar disorder (BD) signals identified by genome-wide association study
(GWAS) often reside in the non-coding regions, understanding the biological relevance of …

Genome-wide association study reveals two new risk loci for bipolar disorder

TW Mühleisen, M Leber, TG Schulze… - Nature …, 2014 - nature.com
Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide
association studies (GWAS) have robustly identified the first common genetic variants …

Systematic genetic analyses of genome‐wide association study data reveal an association between the key nucleosome remodeling and deacetylase complex and …

BO Xiang, K Liu, M Yu, X Liang, J Zhang… - Bipolar …, 2018 - Wiley Online Library
Background Genome‐wide association studies (GWASs) are used to identify genetic
variants for association with bipolar disorder (BD) risk; however, each GWAS can only reveal …

Genetic predictors of gene expression associated with risk of bipolar disorder

KP Shah, HE Wheeler, ER Gamazon, DL Nicolae… - bioRxiv, 2016 - biorxiv.org
Bipolar disorder (BD) affects the quality of life of approximately 1% of the population and
represents a major public health concern. It is known to be highly heritable but large-scale …

Genomics yields biological and phenotypic insights into bipolar disorder

KS O'Connell, M Koromina, T van der Veen, T Boltz… - medrxiv, 2023 - medrxiv.org
Bipolar disorder (BD) is a leading contributor to the global burden of disease. Despite high
heritability (60-80%), the majority of the underlying genetic determinants remain unknown …

Identifying novel proteins underlying bipolar disorder via integrating pQTLs of the plasma, CSF, and brain with GWAS summary data

Z Xiao, N Zheng, H Chen, Z Yang, R Wang… - Translational …, 2024 - nature.com
Bipolar disorder (BD) presents a significant challenge due to its chronic and relapsing
nature, with its underlying pathogenesis remaining elusive. This study employs Mendelian …