Although the Pgp efflux transport protein is overexpressed in resected tissue of patients with
epilepsy, the presence of polymorphisms in MDR1/ABCB1 and MRP2/ABCC2 in patients …

Abstract Background: P-glycoprotein (P-gp), a drug efflux transporter, encoded by the gene
MDR1 ABCB1 multidrug resistant, reduces the penetration through the brain by the AEDs …

Aim: A possible molecular mechanism of clinically defined multidrug-resistant epilepsy
involves drug efflux transporters such as P glycoprotein (P-gp), a member of the ATP …

Aim: To determine the association between polymorphisms of the multidrug transporter
genes ABCC2, ABCC5 and ABCG2, and drug resistance in epilepsy by genotyping …

ABCC2 gene polymorphisms have been shown to be associated with drug-resistant
epilepsy. However, the published results were controversial. To comprehensively re …

Aim: The aim of this study was to replicate a previously reported association between drug
resistance in epilepsy patients and the 24C> T variant of the ABCC2 gene that codes for the …

Objective To assess the association of single nucleotide polymorphisms of multidrug
resistance gene 1 (MDR1) with refractory epilepsy in children. Methods Peripheral blood …

Drug-resistant epilepsy is also referred to as intractable, medically refractory, or
pharmacoresistant epilepsy. Approximately, one-third of patients with epilepsy have …

Despite considerable progress in the pharmacotherapy of epilepsy, more than 30% of
patients are reported to be resistant to antiepileptic drugs. Multidrug resistance 1 (MDR1) …

been satisfied for the transporter hypothesis, however, only in rodent models of epilepsy as
yet [7]. Accordingly, P-gp expression is: increased in epileptogenic brain tissue of rodents; …