Introduction: Influenza antiviral high-throughput screens have been extensive, and yet no
approved influenza antivirals have been identified through high-throughput screening. This …

Drug discovery for influenza antivirals Priorities for combating pandemic influenza include
rapid detection and identification, the quick administration of available drugs to treat the …

Please cite this paper as: Wathen et al.(2012) Antivirals in seasonal and pandemic influenza—
future perspectives. Influenza and Other Respiratory Viruses 7 (Suppl. 1), 76–80. Antiviral …

Influenza viruses (IVs) threaten global human health due to the high morbidity, infection, and
mortality rates. Currently, the influenza drugs recommended by the Food and Drug …

2009 Nature America, Inc. All rights reserved. required for influenza virus replication may
also expand the number of potential targets for the development of antiviral compounds …

Current options for influenza antiviral therapy are limited to the neuraminidase inhibitors,
and knowledge that high levels of oseltamivir resistance have been seen among previously …

Influenza is a century-old disease that continues to baffle humans by its frequently changing
nature, seasonal epidemics, and occasional pandemics. Approximately 9% of the world's …

As resistance of influenza viruses to antiviral agents continues to evolve, new issues arise
concerning appropriate therapy and novel therapeutic means that target influenza infections …

Seasonal and pandemic influenza virus infections not only pose a serious threat to human
health but also cause tremendous economic losses and social burdens. However, due to the …

Using a highly reproducible and robust cell-based high-throughput screening (HTS) assay,
the authors screened a 100,000-compound library at 14-and 114-µM compound …