Several neurodevelopmental and neuropsychiatric disorders are characterized by
intermittent episodes of pathological activity. Although genetic therapies offer the ability to …

Despite the introduction of more than one dozen new antiepileptic drugs in the past 20
years, approximately one-third of people who develop epilepsy continue to have seizures on …

Graded, reversible suppression of neuronal excitability represents a logical goal of therapy
for epilepsy and intractable pain. To achieve such suppression, we have developed the …

Epilepsies are a diverse collection of brain disorders that affect 1–2% of the population.
Current therapies are unsatisfactory as they provide only symptomatic relief, are effective in …

Refractory focal epilepsy is a devastating disease for which there is frequently no effective
treatment. Gene therapy represents a promising alternative, but treating epilepsy in this way …

Epilepsy genes deliver critical insights into the molecular control of brain synchronization
and are revolutionizing our understanding and treatment of the disease. The epilepsy …

BACKGROUND During early mammalian brain development, transient neurons and circuits
form the scaffold for the development of neuronal networks. In the immature cerebral cortex …

Neocortical epilepsy is frequently drug-resistant. Surgery to remove the epileptogenic zone
is only feasible in a minority of cases, leaving many patients without an effective treatment …

Jeffrey L. Noebels steps taken by gene errors to destabilize neural net-Developmental
Neurogenetics Laboratory works; the first practical issue is which gene to select. Department …

The nervous system is vulnerable to perturbations during specific developmental periods.
Insults during such susceptible time windows can have long-term consequences, including …