CD4+ IL9+ (Th9) cells as the major source of IL-9, potentially modulate Th17/Treg mediated host immune response during experimental cerebral malaria
Th9, a new subgroup of CD4+ T cells is characterized by its specific cytokine IL-9, is a critical
factor in allergic diseases, cancers and parasitic infections. This study aimed to explore the …
factor in allergic diseases, cancers and parasitic infections. This study aimed to explore the …
IL-6 dependent expansion of inflammatory MDSCs (CD11b+ Gr-1+) promote Th-17 mediated immune response during experimental cerebral malaria
Myeloid derived suppressor cells (MDSCs) are a group of heterogeneous cell populations
that can suppress T cell responses. Various aspects of MDSCs in regulating immune …
that can suppress T cell responses. Various aspects of MDSCs in regulating immune …
Role of TGF-β and IL-6 in dendritic cells, Treg and Th17 mediated immune response during experimental cerebral malaria
T Keswani, S Sarkar, A Sengupta, A Bhattacharyya - Cytokine, 2016 - Elsevier
The role of cytokines in Plasmodium infection have been extensively investigated, but pro
and anti inflammatory cytokines mediated imbalance during malaria immune-pathogenesis …
and anti inflammatory cytokines mediated imbalance during malaria immune-pathogenesis …
IL-4 treatment mitigates experimental cerebral malaria by reducing parasitemia, dampening inflammation, and lessening the cytotoxicity of T cells
X Wu, RP Thylur, KK Dayanand, K Punnath… - The Journal of …, 2021 - journals.aai.org
Cytokine responses to malaria play important roles in both protective immunity development
and pathogenesis. Although the roles of cytokines such as TNF-α, IL-12, IFN-γ, and IL-10 in …
and pathogenesis. Although the roles of cytokines such as TNF-α, IL-12, IFN-γ, and IL-10 in …
IL-4Rα signaling by CD8α+ dendritic cells contributes to cerebral malaria by enhancing inflammatory, Th1, and cytotoxic CD8+ T cell responses
X Wu, F Brombacher, ZC Chroneos, CC Norbury… - Journal of Biological …, 2021 - ASBMB
Persistent high levels of proinflammatory and Th1 responses contribute to cerebral malaria
(CM). Suppression of inflammatory responses and promotion of Th2 responses prevent …
(CM). Suppression of inflammatory responses and promotion of Th2 responses prevent …
Administration of soluble gp130Fc disrupts M-1 macrophage polarization, dendritic cell activation, MDSC expansion and Th-17 induction during experimental cerebral …
S Mukherjee, S Ghosh, S Bawali, R Chatterjee… - International …, 2023 - Elsevier
Regulatory effect of IL-6 on various immune cells plays a crucial role during experimental
cerebral malaria pathogenesis. IL-6 neutralization can restore distorted ratios of myeloid …
cerebral malaria pathogenesis. IL-6 neutralization can restore distorted ratios of myeloid …
CD4 T-cell subsets in malaria: TH1/TH2 revisited
D Perez-Mazliah, J Langhorne - Frontiers in immunology, 2015 - frontiersin.org
CD4+ T-cells have been shown to play a central role in immune control of infection with
Plasmodium parasites. At the erythrocytic stage of infection, IFN-γ production by CD4+ T …
Plasmodium parasites. At the erythrocytic stage of infection, IFN-γ production by CD4+ T …
T cell-derived IL-10 and its impact on the regulation of host responses during malaria
APF do Rosario, J Langhorne - International journal for parasitology, 2012 - Elsevier
Despite intense research, malaria still is the one of the most devastating diseases killing
more people than any other parasitic infection. In an attempt to control the infection, the host …
more people than any other parasitic infection. In an attempt to control the infection, the host …
IL-33-mediated protection against experimental cerebral malaria is linked to induction of type 2 innate lymphoid cells, M2 macrophages and regulatory T cells
AG Besnard, R Guabiraba, W Niedbala… - PLoS …, 2015 - journals.plos.org
Cerebral malaria (CM) is a complex parasitic disease caused by Plasmodium sp. Failure to
establish an appropriate balance between pro-and anti-inflammatory immune responses is …
establish an appropriate balance between pro-and anti-inflammatory immune responses is …
IL-12Rβ2 is essential for the development of experimental cerebral malaria
M Fauconnier, J Palomo, ML Bourigault… - The Journal of …, 2012 - journals.aai.org
A Th1 response is required for the development of Plasmodium berghei ANKA (PbA)-
induced experimental cerebral malaria (ECM). The role of pro-Th1 IL-12 in malaria is …
induced experimental cerebral malaria (ECM). The role of pro-Th1 IL-12 in malaria is …