Bidirectional DNA replication from a chromosome origin requires the asymmetric loading of
two helicases, one for each replisome. Our understanding of the molecular mechanisms …

DNA replication is a fundamental biological process that is tightly regulated in all cells. In
bacteria, DnaA controls when and where replication begins by building a step‐wise complex …

DNA replication is a fundamental biological process that is tightly regulated in all living cells.
In bacteria, the master regulator DnaA controls when and where replication begins by …

Initiation and re‐initiation of chromosomal DNA replication in bacteria rely on divergent
multiprotein assemblies, which direct the functional delivery of the replicative helicase on …

Genome replication is a fundamental biological activity shared by all organisms.
Chromosomal replication proceeds bidirectionally from origins, requiring the loading of two …

Summary The Bacillus subtilis proteins DnaD and DnaB are essential for replication
initiation and are conserved in low G+ C content Gram‐positive bacteria. Previous work …

ABSTRACT The Bacillus subtilis DnaI, DnaB and DnaD proteins load the replicative ring
helicase DnaC onto DNA during priming of DNA replication. Here we show that DnaI …

Loading of the ring-shaped replicative helicase is a critical step in the initiation of DNA
replication. Bacillus subtilis has adopted a two-protein strategy to load its hexameric …

How cells maintain their ploidy is relevant to cellular development and disease. Here, we
investigate the mechanism by which the bacterium Bacillus subtilis enforces diploidy as it …

Delivery of the replicative helicase onto DNA is an essential step in the initiation of
replication. In bacteria, DnaC (in Escherichia coli) and DnaI (in Bacillus subtilis) are …