An insight into FDA approved antibody-drug conjugates for cancer therapy
The large number of emerging antibody-drug conjugates (ADCs) for cancer therapy has
resulted in a significant market 'boom', garnering worldwide attention. Despite ADCs …
resulted in a significant market 'boom', garnering worldwide attention. Despite ADCs …
Exploration of the antibody–drug conjugate clinical landscape
H Maecker, V Jonnalagadda, S Bhakta… - MAbs, 2023 - Taylor & Francis
The antibody–drug conjugate (ADC) field has undergone a renaissance, with substantial
recent developmental investment and subsequent drug approvals over the past 6 years. In …
recent developmental investment and subsequent drug approvals over the past 6 years. In …
Exploring the next generation of antibody–drug conjugates
Antibody–drug conjugates (ADCs) are a promising cancer treatment modality that enables
the selective delivery of highly cytotoxic payloads to tumours. However, realizing the full …
the selective delivery of highly cytotoxic payloads to tumours. However, realizing the full …
What makes a good antibody–drug conjugate?
M De Cecco, DN Galbraith… - Expert Opinion on …, 2021 - Taylor & Francis
ABSTRACT Introduction: Antibody-Drug Conjugates (ADCs) are becoming increasingly
important weapons in the fight against cancer, as evidenced by the growing number of …
important weapons in the fight against cancer, as evidenced by the growing number of …
Unlocking the potential of antibody–drug conjugates for cancer therapy
Nine different antibody–drug conjugates (ADCs) are currently approved as cancer
treatments, with dozens more in preclinical and clinical development. The primary goal of …
treatments, with dozens more in preclinical and clinical development. The primary goal of …
Targeting cancer with antibody-drug conjugates: Promises and challenges
Antibody-drug conjugates (ADCs) are a rapidly expanding class of biotherapeutics that
utilize antibodies to selectively deliver cytotoxic drugs to the tumor site. As of May 2021, the …
utilize antibodies to selectively deliver cytotoxic drugs to the tumor site. As of May 2021, the …
The evolving landscape of antibody–drug conjugates: In depth analysis of recent research progress
Antibody–drug conjugates (ADCs) are targeted immunoconjugate constructs that integrate
the potency of cytotoxic drugs with the selectivity of monoclonal antibodies, minimizing …
the potency of cytotoxic drugs with the selectivity of monoclonal antibodies, minimizing …
Antibody–drug conjugates come of age in oncology
C Dumontet, JM Reichert, PD Senter… - Nature Reviews Drug …, 2023 - nature.com
Antibody–drug conjugates (ADCs) combine the specificity of monoclonal antibodies with the
potency of highly cytotoxic agents, potentially reducing the severity of side effects by …
potency of highly cytotoxic agents, potentially reducing the severity of side effects by …
Advances in antibody–drug conjugate design: current clinical landscape and future innovations
L Gauzy-Lazo, I Sassoon… - … : Advancing the Science of …, 2020 - journals.sagepub.com
The targeted delivery of potent cytotoxic molecules into cancer cells is considered a
promising anticancer strategy. The design of clinically effective antibody–drug conjugates …
promising anticancer strategy. The design of clinically effective antibody–drug conjugates …