An insight into FDA approved antibody-drug conjugates for cancer therapy

JTW Tong, PWR Harris, MA Brimble, I Kavianinia - Molecules, 2021 - mdpi.com
The large number of emerging antibody-drug conjugates (ADCs) for cancer therapy has
resulted in a significant market 'boom', garnering worldwide attention. Despite ADCs …

Exploration of the antibody–drug conjugate clinical landscape

H Maecker, V Jonnalagadda, S Bhakta… - MAbs, 2023 - Taylor & Francis
The antibody–drug conjugate (ADC) field has undergone a renaissance, with substantial
recent developmental investment and subsequent drug approvals over the past 6 years. In …

Exploring the next generation of antibody–drug conjugates

K Tsuchikama, Y Anami, SYY Ha… - Nature Reviews Clinical …, 2024 - nature.com
Antibody–drug conjugates (ADCs) are a promising cancer treatment modality that enables
the selective delivery of highly cytotoxic payloads to tumours. However, realizing the full …

Antibody–drug conjugates—a tutorial review

S Baah, M Laws, KM Rahman - Molecules, 2021 - mdpi.com
Antibody–drug conjugates (ADCs) are a family of targeted therapeutic agents for the
treatment of cancer. ADC development is a rapidly expanding field of research, with over 80 …

What makes a good antibody–drug conjugate?

M De Cecco, DN Galbraith… - Expert Opinion on …, 2021 - Taylor & Francis
ABSTRACT Introduction: Antibody-Drug Conjugates (ADCs) are becoming increasingly
important weapons in the fight against cancer, as evidenced by the growing number of …

Unlocking the potential of antibody–drug conjugates for cancer therapy

JZ Drago, S Modi, S Chandarlapaty - Nature Reviews Clinical …, 2021 - nature.com
Nine different antibody–drug conjugates (ADCs) are currently approved as cancer
treatments, with dozens more in preclinical and clinical development. The primary goal of …

Targeting cancer with antibody-drug conjugates: Promises and challenges

AQ Dean, S Luo, JD Twomey, B Zhang - MAbs, 2021 - Taylor & Francis
Antibody-drug conjugates (ADCs) are a rapidly expanding class of biotherapeutics that
utilize antibodies to selectively deliver cytotoxic drugs to the tumor site. As of May 2021, the …

The evolving landscape of antibody–drug conjugates: In depth analysis of recent research progress

JM Sasso, R Tenchov, R Bird, KA Iyer… - Bioconjugate …, 2023 - ACS Publications
Antibody–drug conjugates (ADCs) are targeted immunoconjugate constructs that integrate
the potency of cytotoxic drugs with the selectivity of monoclonal antibodies, minimizing …

Antibody–drug conjugates come of age in oncology

C Dumontet, JM Reichert, PD Senter… - Nature Reviews Drug …, 2023 - nature.com
Antibody–drug conjugates (ADCs) combine the specificity of monoclonal antibodies with the
potency of highly cytotoxic agents, potentially reducing the severity of side effects by …

Advances in antibody–drug conjugate design: current clinical landscape and future innovations

L Gauzy-Lazo, I Sassoon… - … : Advancing the Science of …, 2020 - journals.sagepub.com
The targeted delivery of potent cytotoxic molecules into cancer cells is considered a
promising anticancer strategy. The design of clinically effective antibody–drug conjugates …