The arginase enzyme developed in early life forms and was maintained during evolution. As
the last step in the urea cycle, arginase cleaves l-arginine to form urea and l-ornithine. The …

Arginase has roots in early life-forms. It converts L-arginine to urea and ornithine. The former
provides protection against NH 3; the latter serves to stimulate cell growth and other …

As arginine can serve as precursor to a wide range of compounds, including nitric oxide,
creatine, urea, polyamines, proline, glutamate and agmatine, there is considerable interest …

Arginase is a ubiquitous enzyme in the urea cycle (UC) that hydrolyzes L‐arginine to urea
and L‐ornithine. Two mammalian arginase isoforms, arginase1 (ARG1) and arginase2 …

ARGINASE: A CRITICAL REGULATOR OF NITRIC OXIDE SYNTHESIS AND VASCULAR
FUNCTION - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …

Oxidative stress and inflammation in the vascular wall are essential mechanisms of
atherosclerosis and vascular dysfunctions associated with risk factors such as metabolic …

Functional integrity of the vascular endothelium is of fundamental importance for normal
vascular function. A key factor regulating endothelial function is the bioavailability of nitric …

Arginase metabolizes the semi-essential amino acid l-arginine to l-ornithine and urea. There
are two distinct isoforms of arginase, arginase I and II, which are encoded by separate …

Arginase is a widely known enzyme of the urea cycle that catalyzes the hydrolysis of L-
arginine to L-ornithine and urea. The action of arginase goes beyond the boundaries of …

Arginase is a key hydrolase in the urea cycle that hydrolyses L-arginine to urea and L-
ornithine. Increasing number of studies in recent years demonstrate that two mammalian …