In addition to the deregulation of gene transcriptions and post-translational protein
modifications, the aberrant translation from mRNAs to proteins plays an important role in the …

Translational control of mRNAs during gene expression allows cells to promptly and
dynamically adapt to a variety of stimuli, including in neoplasia in response to aberrant …

The translation of cellular mRNA to protein is a tightly controlled process often deregulated
in diseases such as cancer. Furthering our understanding of mRNA structural elements and …

As a convergent mechanism downstream of most oncogenic signals, control of mRNA
translation has emerged as a key driver in establishing and tuning gene expression at …

Translation initiation is regulated in response to nutrient availability and mitogenic
stimulation and is coupled with cell cycle progression and cell growth. Several alterations in …

Recent work has brought to light many different mechanisms of translation initiation that
function in cells in parallel to canonical cap‐dependent initiation. This has important …

The translation of messenger RNAs (mRNAs) into proteins is a key event in the regulation of
gene expression. This is especially true in the cancer setting, as many oncogenes and …

Protein synthesis is a vital cellular process that regulates growth and metabolism. It is
controlled via signaling networks in response to environmental changes, including the …

Remarkable progress has been made in defining a new understanding of the role of mRNA
translation and protein synthesis in human cancer. Translational control is a crucial …

The scanning model for eukaryotic mRNA translation initiation states that the small
ribosomal subunit, along with initiation factors, binds at the cap structure at the 5′ end of …