The human brain has the capacity to rapidly change state, and in epilepsy these state
changes can be catastrophic, resulting in loss of consciousness, injury and even death …

There is an ongoing debate whether generic early warning signals for critical transitions
exist that can be applied across diverse systems. The human epileptic brain is often …

Why seizures spontaneously terminate remains an unanswered fundamental question of
epileptology. Here we present evidence that seizures self-terminate via a discontinuous …

During the past decade, several studies have demonstrated experimental evidence that
temporal lobe seizures are preceded by changes in dynamical properties (both spatial and …

Recent evidence suggests that some seizures are preceded by preictal changes that start
from minutes to hours before an ictal event. Nevertheless an adequate statistical evaluation …

Epilepsy is defined by the seemingly random occurrence of spontaneous seizures. The
ability to anticipate seizures would enable preventative treatment strategies. A central but …

Personalized medicine requires that treatments adapt to not only the patient but also
changing factors within each individual. Although epilepsy is a dynamic disorder …

In a growing number of publications it is claimed that epileptic seizures can be predicted by
analyzing the electroencephalogram (EEG) with different characterizing measures …

To date, the unpredictability of seizures remains a source of suffering for people with
epilepsy, motivating decades of research into methods to forecast seizures. Originally, only …

Abstract The Epilepsy Innovation Institute (Ei2) is a new research program of the Epilepsy
Foundation designed to be an innovation incubator for epilepsy. Ei2 research areas are …