Rising drug resistance among pathogenic fungi, paired with a limited antifungal arsenal,
poses an increasing threat to human health. To identify antifungal compounds, we screened …

Fungal fatty acid (FA) synthase and desaturase enzymes are essential for the growth and
virulence of human fungal pathogens. These enzymes are structurally distinct from their …

Human fungal infections represent a therapeutic challenge. Although effective strategies for
treatment are available, resistance is spreading, and many therapies have unacceptable …

A systematic screen for new natural products that displayed antifungal activity by inhibition of
fungal fatty acid synthase (FAS) led to the discovery of two new fungal metabolites …

Contemporary antifungal therapies utilized to treat filamentous fungal infections are inhibited
by intrinsic and emerging drug resistance. Consequently, there is an urgent need to develop …

Lipids, commonly including phospholipids, sphingolipids, fatty acids, sterols, and
triacylglycerols (TAGs), are important biomolecules for the viability of all cells …

Fatty acid synthase (FAS) has been identified as a potential antifungal target. FAS prepared
from Saccharomyces cerevisiae was employed for bioactivity-guided fractionation of …

The prevalence of drug-resistant pathogenic fungi is a major global health challenge. There
is an urgent need for novel drugs that can exert a potent antifungal activity and overcome …

Fungal diseases today represent a world-wide problem. Poor hygiene and decreased
immunity are the main reasons behind the manifestation of this disease. After COVID-19, an …

Nonadecynoic acid (6-NDA), a plant-derived acetylenic acid, exhibits strong inhibitory
activity against the human fungal pathogens Candida albicans, Aspergillus fumigatus, and …