Although accumulating evidence suggests that activated microglia are associated with
deficits in neurogenesis and contribute to the physiopathology of major depressive disorder …

Aim: Major depressive disorder (MDD) is a debilitating mental disorder associated with
dysfunction of the neurotransmitter-neuroendocrine system and neuroinflammatory …

This study examined whether Salvianolic acid B (Sal B), a major active component of
Chinese herb Radix Salviae Miltiorrhizae, may exert an anti-inflammatory effect in microglia …

Patients with major depressive disorder have elevated peripheral inflammation; the degree
of this increase correlates with the severity of the disorder. Chronic psychological stress …

Rationale Neuroinflammation can be alleviated via M2 microglia polarization, which could
promote the recovery of perimenopausal depression. Astragalin (AST) possesses anti …

The aim of the study was to investigate the effects and possible underlying mechanism of
salidroside (Sal) on lipopolysaccharide (LPS)-induced depression-like behavior in mice. Sal …

Background The natural compound asperosaponin VI has shown potential as an
antidepressant, but how it works is unclear. Here, we explored its effects on mice exposed to …

Background Using drugs to modulate microglial function may be an effective way to treat
disorders, such as depression, that involve impaired neurogenesis. Akebia saponin D (ASD) …

Background The NLRP3 inflammasome activation and neuroinflammation are known to be
involved in the pathology of depression, whereas autophagy has multiple effects on …

Spinal cord injury (SCI) is a severe neurological disease; however, few drugs have been
proved to treat SCI effectively. Neuroinflammation is the major pathogenesis of SCI …