Although nicotine is considered to be responsible for the addictive properties of tobacco,
growing evidence underlines the importance of non‐nicotine components in smoking …

Nicotine is the major neuroactive compound of tobacco, which has, by itself, weak
reinforcing properties. It is known that levels of the enzymes monoamine oxidase A (MAO-A) …

Abstract The Food and Drug Administration (FDA) has the authority to regulate cigarette
smoke constituents, and a reduction in nicotine content might benefit public health by …

Although nicotine is generally considered to be the main compound responsible for the
addictive properties of tobacco, experimental data indicate that nicotine does not exhibit all …

Rationale The mechanisms mediating tobacco addiction remain elusive. Nicotine, the
psychoactive component in tobacco, is generally believed to be the main cause of reward …

In addition to delivering nicotine, tobacco smoke also inhibits monoamine oxidase (MAO).
Although MAO inhibitors (MAOIs) can increase nicotine self-administration in rodents, the …

Although nicotine is generally considered to be the main psychoactive component of
tobacco, growing evidence highlights the importance of nonnicotine compounds in smoking …

Drugs of abuse, such as d-amphetamine or nicotine, are generally considered as acting
through an increased release of dopamine in a subcortical structure, the nucleus …

Aims There have been many reports of monoamine oxidase (MAO) inhibition by non-
nicotine ingredients in tobacco smoke, persisting for days after smoking cessation. This …

Background: There is a hypothesis that substances present in, or derived from, tobacco
smoke inhibit monoamine oxidase (MAO) in the brains of smokers, reducing the degradation …