Background and purpose: The phytocannabinoid, Δ9‐tetrahydrocannabivarin (THCV), can
block cannabinoid CB1 receptors. This investigation explored its ability to activate CB2 …

The widespread plant volatile beta-caryophyllene (BCP) was recently identified as a natural
selective agonist of the peripherally expressed cannabinoid receptor 2 (CB 2). It is found in …

Background and purpose: A nonpsychoactive constituent of the cannabis plant, cannabidiol
has been demonstrated to have low affinity for both cannabinoid CB1 and CB2 receptors …

The Cannabis sativa plant contains more than 120 cannabinoids. With the exceptions of∆ 9-
tetrahydrocannabinol (∆ 9-THC) and cannabidiol (CBD), comparatively little is known about …

Cannabis sativa is the source of a unique set of compounds known collectively as plant
cannabinoids or phytocannabinoids. This review focuses on the manner with which three of …

Cannabidiol (CBD), a nonpsychoactive marijuana constituent, was recently shown as an
oral antihyperalgesic compound in a rat model of acute inflammation. We examined whether …

Cannabinoid CB2 receptors have been implicated in antinociception in animal models of
both acute and chronic pain. We evaluated the role both cannabinoid CB1 and CB2 …

Background and Purpose Cannabichromene (CBC) is one of the most abundant
phytocannabinoids in Cannabis spp. It has modest antinociceptive and anti‐inflammatory …

Background and Purpose: Effects of locally administered agonists and antagonists for
cannabinoid CB1 and CB2 receptors on mechanical and thermal hypersensitivity were …

The cannabinoid agonist, HU210 has been evaluated in vivo in nociceptive and
inflammatory pain models in the rat. The ED50 for the anti-nociceptive (increasing …