Accumulating evidence suggests that the detrimental effect of nicotine and tobacco smoke
on the central nervous system (CNS) is caused by the neurotoxic role of nicotine on blood …

Recent evidence has indicated that active and passive cigarette smoking are associated, in
a dose-dependent manner, with dysfunction of normal endothelial physiology. Tobacco …

Nowadays, tobacco smoking is the cause of~ 5–6 million deaths per year, counting 31% and
6% of all cancer deaths (affecting 18 different organs) in middle-aged men and women …

Cigarette smoking is a preventable risk factor for ischemic stroke. The mechanisms by which
smoking contributes to stroke are poorly understood and the role of nicotine in this process …

Blood-brain barrier (BBB) nicotine transfer has been well documented in view of the fact that
this alkaloid is a cerebral blood flow marker. However, limited data are available that …

Developmental exposure to nicotine in rats results in neurobehavioral effects such as
reduced locomotor and cognitive function. Key events in the animal mode of action (MOA) …

Nicotine and Other Tobacco Compounds in Neurodegenerative and Psychiatric Diseases:
Epidemiological Data on Smoking and Preclinical and Clinical Data on Nicotine provides a …

Cigarette smoking and the use of smokeless chewing tobacco have been closely tied to the
development of several human cancers, including lung, oral, esophageal, and bladder …

Several behavioral studies report that adolescent rats display a preference for nicotine
compared with adults. However, age-related pharmacokinetic differences may confound the …

In the fetus, nicotine is a neuroteratogen that elicits cell damage and loss and subsequent
abnormalities of synaptic function. We explored whether these effects extend into …