The concept of minimal cut sets (MCS) provides a flexible framework for analyzing
properties of metabolic networks and for computing metabolic intervention strategies. In …

The model-driven search for gene deletion strategies that increase the production
performance of microorganisms is an essential part of metabolic engineering. One …

Motivation: Stoichiometric and constraint-based methods of computational strain design
have become an important tool for rational metabolic engineering. One of those relies on the …

Motivation The computer-aided design of metabolic intervention strategies has become a
key component of an integrated metabolic engineering approach and a broad range of …

Various constraint-based optimization approaches have been developed for the
computational analysis and design of metabolic networks. Herein, we present StrainDesign …

One ultimate goal of metabolic network modeling is the rational redesign of biochemical
networks to optimize the production of certain compounds by cellular systems. Although …

The advent of genome‐scale models of metabolism has laid the foundation for the
development of computational procedures for suggesting genetic manipulations that lead to …

Metabolic engineering (ME) efforts have been recently boosted by the increase in the
number of annotated genomes and by the development of several genome-scale metabolic …

Metabolic engineering aims to improve the production of desired biochemicals and proteins
in organisms and therefore, plays a central role in Biotechnology. However, the design of …

Genome-scale metabolic models are increasingly becoming available for a variety of
microorganisms. This has spurred the development of a wide array of computational tools …