This review focuses on vascularization and strategies involved in its evaluation and
modulation. Clinical issues associated with engineered tissues of an atomically relevant size …

Only a few engineered tissues—skin, cartilage, bladder—have achieved clinical success,
and biomaterials designed to replace more complex organs are still far from commercial …

Although there have been extensive research efforts to create functional tissues and organs,
most successes in tissue engineering have been limited to avascular or thin tissues. The …

The field of tissue engineering has turned towards biomimicry to solve the problem of tissue
oxygenation and nutrient/waste exchange through the development of vasculature …

Host integration and performance of engineered tissues have been severely limited by the
lack of robust strategies to generate patent vascularization and tissue perfusion. This review …

Despite the steady increase in the number of studies focusing on the development of tissue
engineered constructs, solutions delivered to the clinic are still limited. Specifically, the lack …

The increasing gap between clinical demand for tissue or organ transplants and the
availability of donated tissue highlights the emerging opportunities for lab-grown or …

There is a tremendous need for organs and tissues to replace those lost due to diseases or
trauma. In theory, transplanting cells on biomaterial matrices can create functional tissue. A …

Vascularization is one of the great challenges that tissue engineering faces in order to
achieve sizeable tissue and organ substitutes that contain living cells. There are instances …

Tissue engineering is currently limited by the inability to adequately vascularize tissues in
vitro or in vivo. Issues of nutrient perfusion and mass transport limitations, especially oxygen …