MRI‐Guided Tumor Therapy Based on Synergy of Ferroptosis, Immunosuppression Reversal and Disulfidptosis

S Guo, Z Li, R Zhou, J Feng, L Huang, B Ren, J Zhu… - Small, 2024 - Wiley Online Library
Triple negative breast cancer (TNBC) cells have a high demand for oxygen and glucose to
fuel their growth and spread, shaping the tumor microenvironment (TME) that can lead to a …

A MOF-based potent ferroptosis inducer for enhanced radiotherapy of triple negative breast cancer

L Zeng, S Ding, Y Cao, C Li, B Zhao, Z Ma, J Zhou… - ACS …, 2023 - ACS Publications
Radiotherapy (RT) is one of the important clinical treatments for local control of triple-
negative breast cancer (TNBC), but radioresistance still exists. Ferroptosis has been …

[HTML][HTML] MR imaging guided iron-based nanoenzyme for synergistic Ferroptosis− Starvation therapy in triple negative breast cancer

D Wang, W Fang, C Huang, Z Chen, T Nie… - Smart Materials in …, 2022 - Elsevier
Triple negative breast cancer (TNBC), as the most aggressive BC, accounts for the leading
cause of worldwide women death. Owing to the deficiency of related hormone receptors, the …

A multi-mode Rhein-based nano-platform synergizing ferrotherapy/chemotherapy-induced immunotherapy for enhanced tumor therapy

X Zhu, L Xie, J Tian, Y Jiang, E Song, Y Song - Acta Biomaterialia, 2024 - Elsevier
Ferroptosis has emerged as a promising strategy for treating triple-negative breast cancer
(TNBC) due to bypassing apoptosis and triggering immunogenic cell death (ICD) of tumor …

Enhanced ferroptosis therapy with a “nano-destructor” by disrupting intracellular redox and iron homeostasis

T Song, G Yang, H Zhang, M Li, W Zhou, C Zheng… - Nano Today, 2023 - Elsevier
Ferroptosis is an iron-dependent form of cell death that is also a promising tumor therapeutic
modality, however, maintaining redox and iron homeostasis in tumor cells limits the …

Functionalized tumor‐targeting nanosheets exhibiting Fe (II) overloading and GSH consumption for ferroptosis activation in liver tumor

K Li, K Xu, Y He, L Lu, Y Mao, P Gao, G Liu, J Wu… - Small, 2021 - Wiley Online Library
Liver tumor is difficult to cure for its high degree of malignancy and rapid progression
characteristics. Ferroptosis as a new model of inducing cell death is expected to break the …

Manganese‐Based Redox Homeostasis Disruptor for Inducing Intense Ferroptosis/Apoptosis Through xCT Inhibition And Oxidative Stress Injury

Q Dong, J Wang, J Liu, L Zhang, Z Xu… - Advanced …, 2023 - Wiley Online Library
Intracellular redox homeostasis plays an important role in promoting tumor progression,
development and even treatment resistance. To this end, redox balance impairment may …

Self-cascade nanohybrids boost cell ferroptosis stress for tumor radiosensitization therapy

Q Wu, M Hou, P Zhang, Y Jiang, M Liu, L Xiong… - Applied Materials …, 2022 - Elsevier
Although ferroptosis plays a potential role in sensitizing tumor radiotherapy, its
radiosensitization efficacy is still limited by insufficient endogenous H 2 O 2 and excess …

Precision therapy through breaking the intracellular redox balance with an MOF-based hydrogel intelligent nanobot for enhancing ferroptosis and activating …

D Zhang, Y Meng, Y Song, P Cui, Z Hu, X Zheng - Nanoscale, 2022 - pubs.rsc.org
With the advancement and development of nanomedicine, tumor precision therapy provides
technical support for effective accumulation and targeted drug delivery, and reduces toxic …

A tumor microenvironment responsive nanoplatform with oxidative stress amplification for effective MRI-based visual tumor ferroptosis

S Luo, D Ma, R Wei, W Yao, X Pang, Y Wang, X Xu… - Acta Biomaterialia, 2022 - Elsevier
As a promising new form of non-apoptotic regulated cell death, ferroptosis has potential as
an effective supplement to apoptosis-based cancer treatments. However, high intracellular …