A “weird” mitochondrial fatty acid oxidation as a metabolic “secret” of cancer
Cancer metabolism is an extensively studied field since the discovery of the Warburg effect
about 100 years ago and continues to be increasingly intriguing and enigmatic so far. It has …
about 100 years ago and continues to be increasingly intriguing and enigmatic so far. It has …
Cancer metabolism: fatty acid oxidation in the limelight
Warburg suggested that the alterations in metabolism that he observed in cancer cells were
due to the malfunction of mitochondria. In the past decade, we have revisited this idea and …
due to the malfunction of mitochondria. In the past decade, we have revisited this idea and …
Mitochondria in cancer energy metabolism: culprits or bystanders?
A Kim - Toxicological research, 2015 - Springer
Cancer is a disease characterized by uncontrolled growth. Metabolic demands to sustain
rapid proliferation must be compelling since aerobic glycolysis is the first as well as the most …
rapid proliferation must be compelling since aerobic glycolysis is the first as well as the most …
[HTML][HTML] The role of mitochondrial fat oxidation in cancer cell proliferation and survival
MP De Oliveira, M Liesa - Cells, 2020 - mdpi.com
Tumors remodel their metabolism to support anabolic processes needed for replication, as
well as to survive nutrient scarcity and oxidative stress imposed by their changing …
well as to survive nutrient scarcity and oxidative stress imposed by their changing …
[HTML][HTML] Expanding the concepts of cancer metabolism
Since Otto Warburg first proposed that cancer cells have defective mitochondrial metabolism
with enhanced aerobic glycolysis almost 100 years ago, uncovering the unique metabolic …
with enhanced aerobic glycolysis almost 100 years ago, uncovering the unique metabolic …
[HTML][HTML] The tumor suppressor function of mitochondria: translation into the clinics
JM Cuezva, ÁD Ortega, I Willers… - … et Biophysica Acta (BBA …, 2009 - Elsevier
Recently, the inevitable metabolic reprogramming experienced by cancer cells as a result of
the onset of cellular proliferation has been added to the list of hallmarks of the cancer cell …
the onset of cellular proliferation has been added to the list of hallmarks of the cancer cell …
[HTML][HTML] Metabolic alterations in cancer cells and the emerging role of oncometabolites as drivers of neoplastic change
Z Zhou, E Ibekwe, Y Chornenkyy - Antioxidants, 2018 - mdpi.com
The mitochondrion is an important organelle and provides energy for a plethora of
intracellular reactions. Metabolic dysregulation has dire consequences for the cell, and …
intracellular reactions. Metabolic dysregulation has dire consequences for the cell, and …
Mitochondrial free fatty acid β-oxidation supports oxidative phosphorylation and proliferation in cancer cells
S Rodríguez-Enríquez, L Hernández-Esquivel… - The international journal …, 2015 - Elsevier
Oxidative phosphorylation (OxPhos) is functional and sustains tumor proliferation in several
cancer cell types. To establish whether mitochondrial β-oxidation of free fatty acids (FFAs) …
cancer cell types. To establish whether mitochondrial β-oxidation of free fatty acids (FFAs) …
[HTML][HTML] Mitochondrial and metabolic alterations in cancer cells
J Di Gregorio, S Petricca, R Iorio, E Toniato… - European journal of cell …, 2022 - Elsevier
Metabolic alterations have been observed in many cancer types. The deregulated
metabolism has thus become an emerging hallmark of the disease, where the metabolism is …
metabolism has thus become an emerging hallmark of the disease, where the metabolism is …
[HTML][HTML] Metabolic plasticity in cancer cells: reconnecting mitochondrial function to cancer control
VK Ramanujan - Journal of cell science & therapy, 2015 - ncbi.nlm.nih.gov
Anomalous increase in glycolytic activity defines one of the key metabolic alterations in
cancer cells. A realization of this feature has led to critical advancements in cancer detection …
cancer cells. A realization of this feature has led to critical advancements in cancer detection …