Inverted DNA repeats are an at-risk motif for genetic instability that can induce both deletions
and recombination in yeast. We investigated the role of the length of inverted repeats and …

Meiotic recombination in Saccharomyces cerevisiae involves the formation of
heteroduplexes, duplexes containing DNA strands derived from two different homologues. If …

We have constructed novel DNA substrates (one inverted and three direct repeats) based on
the same 0.6-kb repeat sequence to study deletions and inversions in Saccharomyces …

Inverted DNA repeats are known to cause genomic instabilities. Here we demonstrate that
double-strand DNA breaks (DSBs) introduced a large distance from inverted repeats in the …

Large-scale changes (gross chromosomal rearrangements [GCRs]) are common in
genomes, and are often associated with pathological disorders. We report here that a …

Small direct repeats, which are frequent in all genomes, are a potential source of genome
instability. To study the occurrence and genetic control of repeat-associated deletions, we …

The presence of repeated sequences in the genome represents a potential source of
karyotypic instability. Genetic control of recombination is thus important to preserve the …

The preservation of sequence homogeneity and copy number of tandemly repeated genes
may require specific mechanisms or regulation of recombination. We have identified …

Intrachromosomal recombination between direct repeats can occur either as gene
conversion events, which maintain exactly the number of repeat units, or as deletions, which …

Spontaneous and double-strand break (DSB)-induced allelic recombination in yeast was
investigated in crosses between ura3 heteroalleles inactivated by an HO site and a+ 1 …