Inter-individual variability in drug response, be it efficacy or safety, is common and likely to
become an increasing problem globally given the growing elderly population requiring …

Despite the marked advances in drug therapy, some patients do not respond favorably or
suffer severe adverse drug effects. Pharmacogenetic studies have shown that …

The subject area of pharmacogenetics, also known as pharmacogenomics, has a long
history. Research in this area has led to fundamental discoveries, which have helped our …

Pharmacogenetics is the study of the role of inheritance in inter-individual variation in drug
response. Since its origins in the mid-twentieth century, a major driving force in …

There is great heterogeneity in the way humans respond to medications, often requiring
empirical strategies to find the appropriate drug therapy for each patient (the “art” of …

Research on genes and medications has advanced our understanding of the genetic basis
of individual drug responses. The aim of pharmacogenomics is to develop strategies for …

The ability to predict a patient's drug response on the basis of their genetic information is
expected to decrease attrition during the development of new, innovative drugs, and reduce …

Pharmacogenetics and pharmacogenomics involve the study of the role of inheritance in
individual variation in drug response, a phenotype that varies from potentially life …

Interindividual variability in genes encoding drug-metabolizing enzymes, transporters,
receptors, and human leukocyte antigens has a major impact on a patient's response to …

Pharmacogenetics and pharmacogenomics deal with the genetic basis underlying variable
drug response in individual patients. The traditional pharmacogenetic approach relies on …