The chemical syntheses of RNA oligomers containing modifications on the 5′‐carbon of
the 5′‐terminal nucleoside for crystallographic and mechanistic studies of the hairpin …

Due to the development in the field of RNA synthesis over the past decade of years,
preparation of RNA oligonucleotides longer than 50 nucleotides is possible today. In this …

The hairpin ribozyme achieves catalytic cleavage through interaction of essential
nucleotides located in two distinct helical domains that include internal loops. Initial docking …

The hairpin ribozyme catalyzes site-specific cleavage of an RNA substrate using a
magnesium-dependent transphosphorylation mechanism. Here, we describe experiments …

Abstract We introduced 4-thio-(4SU), 2-thio-(2SU), 4-O-methyl-uridine (4MeU) and cytidine
substitutions for U+ 2, which is an important base for cleavage in a substrate RNA …

The catalytic function of the hairpin ribozyme has been investigated by modification-
interference analysis of both ribozyme and substrate, using ribonucleoside …

We have carried out an in vitro selection to obtain an allosteric hairpin ribozyme, which has
cleavage activity in the presence of an exogenous short oligonucleotide as a regulator …

Hairpin ribozymes with high cleavage activities were designed. An extra sequence was
introduced at the 3′-end of the hairpin ribozyme to increase the binding to the substrate …

The hairpin ribozyme is a small self-cleaving RNA that can be engineered for RNA cleavage
in trans and has potential as a therapeutic agent. We have used a chemical synthesis …

The hairpin ribozyme is an example of a small catalytic RNA that catalyses the
endonucleolytic transesterification of RNA in a highly sequence-specific manner. We have …