Insights into the poor prognosis of allopurinol-induced severe cutaneous adverse reactions: the impact of renal insufficiency, high plasma levels of oxypurinol and …
WH Chung, WC Chang, SL Stocker, CG Juo… - Annals of the …, 2015 - ard.bmj.com
Objective Allopurinol, an antihyperuricaemic agent, is one of the common causes of life-
threatening severe cutaneous adverse reactions (SCAR), including drug rash with …
threatening severe cutaneous adverse reactions (SCAR), including drug rash with …
Racial/ethnic variation and risk factors for allopurinol-associated severe cutaneous adverse reactions: a cohort study
Objectives To examine associations of race/ethnicity and purported risk factors with
hospitalised allopurinol-associated severe cutaneous adverse reactions (AASCARs) …
hospitalised allopurinol-associated severe cutaneous adverse reactions (AASCARs) …
Allopurinol hypersensitivity: Pathogenesis and prevention
LK Stamp, PT Chapman - Best practice & research Clinical rheumatology, 2020 - Elsevier
Allopurinol, a first line urate-lowering therapy, has been associated with serious cutaneous
reactions that have a high mortality. A number of risk factors for these serious adverse …
reactions that have a high mortality. A number of risk factors for these serious adverse …
Relation between adverse events associated with allopurinol and renal function in patients with gout
J Vazquez-Mellado, EM Morales… - Annals of the …, 2001 - ard.bmj.com
BACKGROUND Because serious adverse reactions to allopurinol have been related to a
reduce creatinine clearance rate and prolonged half life of oxypurinol, it has been …
reduce creatinine clearance rate and prolonged half life of oxypurinol, it has been …
Severe cutaneous reactions requiring hospitalization in allopurinol initiators: a population‐based cohort study
SC Kim, C Newcomb, D Margolis, J Roy… - Arthritis care & …, 2013 - Wiley Online Library
Objective Rare but potentially life‐threatening cutaneous adverse reactions have been
associated with allopurinol, but population‐based data on the incidence and mortality of …
associated with allopurinol, but population‐based data on the incidence and mortality of …
Allopurinol initiation and all-cause mortality in the general population
Background Allopurinol is the most commonly used urate-lowering therapy, with rare but
potentially fatal adverse effects. However, its impact on overall mortality remains largely …
potentially fatal adverse effects. However, its impact on overall mortality remains largely …
Allopurinol hypersensitivity: investigating the cause and minimizing the risk
LK Stamp, RO Day, J Yun - Nature Reviews Rheumatology, 2016 - nature.com
Allopurinol is the most commonly prescribed urate-lowering therapy for the management of
gout. Serious adverse reactions associated with allopurinol, while rare, are feared owing to …
gout. Serious adverse reactions associated with allopurinol, while rare, are feared owing to …
Acute adverse reactions attributed to allopurinol in hospitalised patients.
GT McInnes, DH Lawson, H Jick - Annals of the Rheumatic Diseases, 1981 - ard.bmj.com
Of 29 524 hospitalised medical patients monitored in a drug surveillance programme 1835
(6.2%) received the xanthine oxidase inhibitor allopurinol. After the exclusion of skin …
(6.2%) received the xanthine oxidase inhibitor allopurinol. After the exclusion of skin …
How to prevent allopurinol hypersensitivity reactions?
LK Stamp, ML Barclay - Rheumatology, 2018 - academic.oup.com
Allopurinol hypersensitivity syndrome (AHS) is a severe and sometimes life-threatening
adverse drug reaction. Although AHS is rare, the number of patients with gout requiring …
adverse drug reaction. Although AHS is rare, the number of patients with gout requiring …
Starting dose is a risk factor for allopurinol hypersensitivity syndrome: a proposed safe starting dose of allopurinol
LK Stamp, WJ Taylor, PB Jones… - Arthritis & …, 2012 - Wiley Online Library
Objective Allopurinol is the most commonly used urate‐lowering therapy in gout. Allopurinol
hypersensitivity syndrome (AHS) is a rare but potentially fatal adverse event. Dosing …
hypersensitivity syndrome (AHS) is a rare but potentially fatal adverse event. Dosing …