Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

DA Butterfield, B Halliwell - Nature Reviews Neuroscience, 2019 - nature.com
Alzheimer disease (AD) is a major cause of age-related dementia. We do not fully
understand AD aetiology and pathogenesis, but oxidative damage is a key component. The …

Metabolic dysregulation contributes to the progression of Alzheimer's disease

X Yan, Y Hu, B Wang, S Wang, X Zhang - Frontiers in neuroscience, 2020 - frontiersin.org
Alzheimer's disease (AD) is an incurable neurodegenerative disease. Numerous studies
have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis …

Glycolytic metabolism, brain resilience, and Alzheimer's disease

X Zhang, N Alshakhshir, L Zhao - Frontiers in Neuroscience, 2021 - frontiersin.org
Alzheimer's disease (AD) is the most common form of age-related dementia. Despite
decades of research, the etiology and pathogenesis of AD are not well understood. Brain …

Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease

L Mosconi, A Pupi, MJ De Leon - … of the New York Academy of …, 2008 - Wiley Online Library
One of the main features of Alzheimer's disease (AD) is the severe reduction of the cerebral
metabolic rate for glucose (CMRglc). In vivo imaging using positron emission tomography …

Impaired peripheral glucose homeostasis and Alzheimer's disease

N Wijesekara, RA Gonçalves, FG De Felice… - …, 2018 - Elsevier
Alzheimer's disease (AD) is the most common type of dementia. Recent studies suggest that
metabolic disturbances, particularly type 2 diabetes (T2D) increase the risk of cognitive …

Altered glucose metabolism in Alzheimer's disease: role of mitochondrial dysfunction and oxidative stress

S Dewanjee, P Chakraborty, H Bhattacharya… - Free Radical Biology …, 2022 - Elsevier
Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …

Metabolic dysfunction in Alzheimer's disease: from basic neurobiology to clinical approaches

JR Clarke, FC Ribeiro, RL Frozza… - Journal of …, 2018 - content.iospress.com
Clinical trials have extensively failed to find effective treatments for Alzheimer's disease (AD)
so far. Even after decades of AD research, there are still limited options for treating …

Alzheimer's disease–synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts

G Münch, R Schinzel, C Loske, A Wong… - Journal of neural …, 1998 - Springer
Many approaches have been undertaken to understand Alzheimer's disease (AD) but the
heterogeneity of the etiologic factors makes it difficult to define the clincally most important …

Oxidative stress, protein modification and Alzheimer disease

A Tramutola, C Lanzillotta, M Perluigi… - Brain research bulletin, 2017 - Elsevier
Alzheimer disease (AD) is a progressive neurodegenerative disease that affects the elderly
population with complex etiology. Many hypotheses have been proposed to explain different …

Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer's disease

FG De Felice, MV Lourenco - Frontiers in aging neuroscience, 2015 - frontiersin.org
Brain metabolic dysfunction is known to influence brain activity in several neurological
disorders, including Alzheimer's disease (AD). In fact, deregulation of neuronal metabolism …